For a study, the researchers sought to support treatment and healthcare funding decisions by providing an up-to-date systematic assessment of peer-reviewed research evaluating the cost-effectiveness of Percutaneous vertebral augmentation (VA) procedures, vertebroplasty (VP), or KP for Osteoporotic vertebral fractures (OVFs). The research was a systematic review of the literature and structured narrative synthesis. Cost-effectiveness research for VA procedures VP or balloon kyphoplasty (BK) for OVFs was peer-reviewed. Report country and year, outline design, comparators, population, perspective, health appraisals, costing sources, and cost-effectiveness metrics were all collected from the outcomes. In addition, model type, time horizon, major model drivers, and uncertainty handling were retrieved for economic studies utilizing modeling. The key cost-effectiveness measure was the incremental cost-effectiveness ratio (ICER), the ratio of differences in costs and health benefits between comparative treatment groups. Until the review date of May 2021, a systematic review of the databases MEDLINE, EMBASE, CINAHL, ECONLIT, Cochrane Library and DARE was done. Researchers looked for outlines that included cost-effectiveness assessments of VA procedures such as VP or BK for OVFs. Cost-only research, abstracts, editorials, methodology, and reviews were excluded. The articles were chosen by PRISMA guidelines. A descriptive framework was created to categorize different cost-effectiveness research based on methodological variations, and papers were summarised using a structured narrative synthesis. The British Medical Journal checklist for individual cost-effectiveness studies and the CiCERO checklist for systematic reviews of cost-effectiveness studies were used to assess quality. In this systematic review, 520 references were found through database searches, with 501 of them being ruled out due to titles and abstracts that did not meet the prior eligibility criteria. As a result, 10 publications were found appropriate for the systematic review evaluating the cost-effectiveness of VA procedures for OVFs after full-text reviews of 19 reports. Between 2008 and 2020, all references were published. All 10 cost-effectiveness studies used CM for OVFs as a treatment comparator, 3 for VP, 3 for BK, and 4 for VP and BK. Diverse economic analysis approaches, modeling assumptions, cost, and health appraisals were used in different healthcare settings over different periods in the studies.