For a study, researchers sought to compare hemodynamic instability during continuous, intermittent, and hybrid renal replacement therapy (RRT) in critically ill patients and its relationship with renal recovery and mortality. The PRISMA guidelines carried out the search, which was recorded in the PROSPERO database. RCTs were included for critically ill patients with acute kidney injury (AKI) treated with continuous, intermittent, or hybrid RRT. PubMed, Embase, and Cochrane were used in the search. The systematic review included 12 RCTs representing 1,419 patients from the 3,442 citations. Most studies (n=8) found no differences in hemodynamic parameters between RTT modalities. The prevalence of hypotensive episodes ranged from 5% to 60%. There were significant differences in heart rate and blood pressure between studies. However, studies showed significant heterogeneity in outcome definitions and measurement, making meta-analysis impossible. In addition, there was very little data on the hemodynamic tolerance of renal replacement therapy methods. Before conclusions could be drawn, better standardization of hemodynamic tolerance and additional reports were required.