Effects of randomization studies affiliation 6 lack city information, which was required by established norms. Verify that the city is correct and update if necessary. Results on the effects of tight glycemic control (TGC) and the resulting hypoglycemia on long-term neurodevelopmental consequences have been inconclusive. The researchers looked into this link in young patients undergoing heart surgery. Neurodevelopmental (ND) follow-up was conducted on patients participating in the Safe Pediatric Euglycemia After Cardiac Surgery (SPECS) experiment between the ages of 30 and 42.5 months. The Bayley Scales of Infant and Toddler Development, Third Edition, was used to evaluate the effects of ND. Patients with moderate to severe hypoglycemia and those with minimal or mild hypoglycemia were compared across TGC and standard care therapy groups using ND ratings. To further evaluate differences between groups longitudinally, the researchers coupled the assessments at 3 years of age with those gathered at less than 30 months of age as a secondary analysis to boost sample size and power. There were no statistically significant variations in ND outcomes across treatment groups or hypoglycemic status among the 269 participants who completed neurodevelopmental evaluation (in-person testing or questionnaires) at 3 years of age (follow-up rate, 31%). When all assessments (conducted between ages 9 and 42.5) were considered, the researchers discovered no differences between the therapy groups. In these longitudinal analyses, children with moderate to severe hypoglycemia scored lower on the Bayley-III cognitive and motor domains than children with no or mild hypoglycemia.