Although research has linked pre-existing intratumoral immune response—characterized by presence of tumor-infiltrating lymphocytes or cytotoxic effector T cells—with improve prognosis in early triple-negative breast cancer (eTNBC) but suggest that immune-rich tumors are not prognostic in metastatic TNBC (mTNBC), whether the T-cell immune biology has differential prognosis between eTNBC and mTNBC remains unclear, as different immune biomarkers were used across studies to make these observations. For a study, researchers evaluated the prognostic value of the T effector RNA gene signature (Teff), across two eTNBC and two mTNBC clinical studies using the same biomarker methodology. Although Teff levels were similar within the eTNBC studies and within the mTNBC studies, Teff score was significantly higher in the eTNBC studies. Among baseline prognostic characteristics assessed, lymph node involvement in the eTNBC studies was the only one associated with Teff. Multivariate analysis found elevated Teff to be associated with improved overall survival in two eTNBC studies but to have no prognostic value in two mTNBC trials. Similar results were seen at various Teff cutoffs.
Meeting Coverage
- ASCO – Lung CancerASCO.20 Virtual Scientific Program, held May 29 - 31, brought professionals from all over the world together to hear the brightest minds in oncology present state-of-the-art treatment modalities and new therapies.
- AACR-2020The American Association for Cancer Research is the world's oldest and largest professional association related to cancer research.
- ACC 2020The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. However, ACC.20/WCC Virtual Meeting continues to release cutting edge science and practice changing updates for cardiovascular professionals on demand and free through June 2020.
- ENDO: 2020ENDO 2020 Annual Conference has been canceled due to COVID-19. Here are highlights of emerging data that has still been released. Keep an eye out for ENDO Online 2020, which will take place from June 8 to 22.
- CROI 2020Every year, CROI hosts some of the world's leading experts in HIV research, who come to present exciting new data and drive forward the field of HIV/AIDS research. This year, due to COVID-19, CROI held their meeting virtually.
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ASCO 2019The 2019 ASCO Annual Meeting, taking place May 31-June 4 in Chicago, will bring together more than 32,000 oncology professionals from across the globe. The theme of this year’s conference is Caring for Every Patient, Learning From Every Patient.