Acne vulgaris is a persistent skin condition that affects hair follicles and sebaceous glands. Skin microorganisms are one of the many variables that contribute to the condition. The skin microbiome in the follicle is made up of a varied collection of microorganisms. Propionibacterium acnes and Malassezia spp., for example, have been related to acne development due to their effects on sebum production, comedone formation, and inflammatory response. 

For the past four decades, antibiotics that target P. acnes have been the cornerstone of acne therapy. The most commonly given are macrolides, clindamycin, and tetracyclines. Understanding the skin microbiome associated with acne and the impact of antibiotic usage on skin commensals is very relevant and crucial for doctors as antibiotic resistance becomes an increasing problem in clinical practice. 

Researchers have highlighted in recent studies the makeup and dynamics of the acne skin microbiome, as well as the impact of antibiotic therapy on skin microorganisms.