Researchers discovered Edwardsiella tarda (E. tarda), a gram-negative, facultative anaerobic bacteria. Gastroenteritis is the most common sign of an E. tarda infection. However, parenteral infections and diseases of the hepatobiliary system can affect immunocompromised hosts. E. tarda-caused sepsis had a dismal prognosis, with a mortality rate of 38%. Researchers reported on a case of E. tarda-related septic shock and bloodstream infection following an acute cholecystitis diagnosis. A 64-year-old man presented with a fever and severe upper abdominal pain due to acute cholecystitis caused by a hepatitis B virus infection. The patient presented with complaints of pain in the upper right region of their stomach, as well as nausea, vomiting, fever, and jaundice. Computed Tomography scans revealed gallstones and blockages in the common bile duct. Acute cholangitis and choledocholithiasis were diagnosed and treated via surgery. Because of the septic shock, a blood culture was analyzed, and Escherichia tarda was found to be the main pathogen. Procedures include cholecystectomy, choledocholithotomy, T-tube drainage, and intravenous antibiotics. The patient recovered rapidly after the operation. Diseases and parenteral and intestinal infections caused by E. tarda were rare, but they can spread rapidly and prove fatal. Parenteral infections should be treated with antibiotics as soon as possible, but prompt surgery may also be necessary in some cases.