For a study, researchers sought to assess the obstetric and neonatal outcomes of the first live birth delivered 1 or more years after receiving a breast cancer diagnosis.
In a population-based analysis, they compared the live birth rates of matched women without a history of cancer (the control group) versus women with a history of breast cancer (the case group). Individuals in the case and control groups were identified using connected data from the California Cancer Registry and California Office of Statewide Health Planning and Development data sets. The case group included people diagnosed with stage I-III breast cancer between the ages of 18 and 45 between January 1, 2000, and December 31, 2012, and who had their first child at least 12 months following their diagnosis. Covariate-matched women who gave birth between 2000 and 2012 and had no history of breast cancer made up the control group of participants. Preterm delivery at fewer than 37 weeks gestation was the main result. Secondary outcomes were cesarean delivery, severe maternal morbidity, small for gestational age (SGA), preterm birth at fewer than 32 weeks, and neonatal morbidity. Subgroup analyses were utilized to examine the impact on the outcomes of interest of the interval between the initial treatment and conception and the receipt of additional adjuvant therapy before pregnancy.
Over 553 of the 30,021 women between the ages of 18 and 45 diagnosed with stage I–III breast cancer between 2000 and 2012 met the requirements for the research. Preterm birth at less than 37 weeks of gestation was equally likely among those with a history of breast cancer and matched women in the control group (odds ratio [OR], 1.29; 95% CI, 0.95–1.74), as was preterm birth at less than 32 weeks of gestation (OR, 0.77; CI, 0.34–1.79), delivering an SGA neonate (less than the 5th percentile: OR 0.60; 95% CI 0.35–1.03; less than the 10th percentile: OR 0.94; 95% CI 0.68–1.30), and experiencing severe maternal morbidity (OR 1.61; 95% CI 0.74–3.50). Compared to women in the control group, patients with a history of breast cancer had greater chances of having a cesarean birth (OR 1.25; 95% CI 1.03-1.53), but their kids did not have higher odds of newborn morbidity (OR 1.15; 95% CI 0.81-1.62).
Breast cancer 1 or more years before fertilization was not substantially related to obstetric and neonatal problems.