For a study, researchers sought to determine how sex and age differences interacted with All-Terrain Vehicle (ATV)-related emergency department visits for a study. For ATV-related emergency department (ED) visits, data from the 2019 National Electronic Injury Surveillance System was extracted, including sex, age, race, the crash site, injured body part, and if alcohol was involved. Investigators used descriptive statistics and logistic regression analysis. They used separate multivariable models to model sex and adjusted for the same independent variables. ATV-related ED visits accounted for 95,995 (unweighted n=1999) visits. In comparing ATV-related ED visits vs. other ED injuries, there was a significant age-by-sex interaction, demonstrating that the influence of age on ATV-related ED visits differed by sex and vice versa. Males were 1.7 times as likely than females to visit the emergency room because of an ATV. Girls younger than 18 years (adjusted odds ratio [AOR] 2.33; 95% CI 1.61–3.69) and women aged 18–35 years (AOR 4.76; 95% CI 3.48–6.51) had significantly higher odds than women older than 35 years in the stratified analysis for female individuals. When comparing men aged 18–35 (AOR 2.21; 95% CI 1.72–2.85) to men older than 35, the odds were significantly higher for men aged 18–35 (AOR 2.21; 95% CI 1.72–2.85). As newer ATVs got more powerful and quicker, it was important to understand who’s at risk for ATV-related ED visits so that legislation and safety measures might be developed.