Contact lens-induced papillary conjunctivitis (CLPC) is a frequent ocular allergy condition in people who wear contact lenses. In its most extreme form, it can produce large papillary conjunctivitis, which can lead to contact lens intolerance and the need to stop wearing contact lenses. This review discusses the etiology, clinical symptoms, and treatment options for this prevalent disease. The severity of CLPC varies according to the type of contact lenses used. Refitting patients with silicone hydrogel contact lenses or daily disposable contact lenses may alleviate CLPC symptoms. The topical immunomodulatory drug tacrolimus, which was recently approved for use in other severe allergic eye disorders, may be useful in reducing allergic inflammation in CLPC as well.

CLPC is a frequent ocular disease among contact lens wearers that has a substantial influence on vision quality. It should be quickly detected by healthcare practitioners and controlled through changes in contact lens types and wearing schedules, as well as new therapy options using topical immunomodulators.