To highlight and discuss promising early research behind a variety of alternative erectile dysfunction treatments and therapies (ED). With growing consumer interest, alternative therapies for ED are becoming more common. Online, “natural” goods are offered, and several clinics provide a variety of off-label and experimental therapies. These alternative therapies have shown different degrees of effectiveness in randomized studies and meta-analyses, but none of them has strong enough evidence to be deemed first-line therapy. These therapies may be utilized in conjunction with standard treatments or in new penile rehabilitation research procedures.

With the rising interest in alternative treatments for men’s health, patient counsel must be well-versed in the literature. Alternative therapies, like L-arginine, have a growing body of data for effectiveness when combined with PDE5i, while low-intensity shock wave therapy and stem cell therapy continue to show promising results in ED studies.