A Well-designed clinical research must yield useful data to the broader public. However, most recent research does not contain significant cohorts of racial/ethnic minorities. Underrepresentation may result in delayed or incorrect disease diagnosis, widespread use of approved interventions without adequate understanding of their effectiveness in specific populations, and the production of not universally applicable recommendations. Develop best practices for racial/ethnic minority recruitment and retention in pulmonary, critical care, and sleep clinical medicine research.

In May, the American Thoracic Society held a workshop. This workshop featured a worldwide interprofessional group with experience ranging from clinical and biomedical research to community-based participatory research methodologies and patient advocacy from academia, business, the NIH, and the US Food and Drug Administration. Participants in the workshop discussed historical and current scientific research skepticism, systematic bias, and social and institutional impediments to minority participation in clinical research. Researchers conducted a PubMed and Google Scholar search to back up the findings. The search was not intended to be a comprehensive survey of the literature. Minority engagement in clinical research is hampered by barriers at the individual, interpersonal, institutional, and federal/policy levels. Workshop participants presented evidence-based remedies to the identified problems using a multilayered framework. Minority engagement in clinical research is not indicative of the United States or the world. This research statement from the American Thoracic Society identifies potential evidence-based remedies using a tiered structure focused on community engagement and patient advocacy.