This study states that The clinical indications of leptospirosis can change generally, which confuses opportune analysis and focused on treatment. Aseptic meningitis related with Leptospira disease, in the future named leptospirosis-related meningitis (LAM), has been all around portrayed. Nonetheless, clinicians analyze abnormal types of leptospirosis less regularly, especially without exemplary signs. Identification requires a significant degree of clinical doubt, and surprisingly then defective diagnostics for leptospirosis limit opportune affirmation. Leptospirosis causes »1 million ailments yearly; this figure does exclude LAM (4). Regardless of the great worldwide weight of leptospirosis and early information that anicteric LAM is overlooked (1), scarcely any current investigations depict the extent of aseptic meningitis brought about by Leptospira sp. disease in settings in which it is endemic. We performed reconnaissance for aseptic meningitis in a space of high transmission of metropolitan leptospirosis. Emergency clinic Couto Maia, the Oswaldo Cruz Foundation, and Yale University gave morals endorsement to this investigation. . We enlisted continuous patients >5 years old who had an analysis of aseptic meningitis, characterized by clinical meningitis (fever with serious migraine or meningismus); nonturbid, nonpurulent cerebrospinal liquid (CSF) containing 10–2,000 cells/m3, protein <150 mg/dL, glucose >40 mg/dL; and adverse outcomes for bacterial meningitis on Gram stain, culture segregation, and latex agglutination tests.

Reference link- https://wwwnc.cdc.gov/eid/article/26/9/19-1001_article