Higher carotid-femoral pulse wave velocity (CFPWV) and an expanded danger of cardiovascular disease (CVD) are related to increased central pulse pressure. A more modest aortic root diameter (AoR) is related to higher focal pulse pressure. We hypothesized that the mix of a more modest aortic root diameter and higher CFPWV is related to expanded CVD hazard (in comparison to a bigger aortic root diameter and lower CFPWV). We tried this speculation in a locally based Framingham Study (N=1970, mean age 60 years, 57% female). We made gender-specific longitudinal echocardiographic AoR trajectories for more than twenty years, classifying members into more modest versus bigger AoR gatherings. We cross-arranged members dependent on their aortic root diameter path and CFPWV (dichotomized at the gender-specific median). We utilized Cox regression to relate the cross-ordered gatherings to CVD occurrence on follow-up (median years = 17): lower CFPWV, bigger AoR (referent gathering; 6.4/1000 person-years); lower CFPWV, reduced aortic root diameter (6.9/1000 person-years); higher carotid-femoral pulse wave velocity, bigger AoR (23.1/1000 person-years); and higher CFPWV, more modest AoR (21.9/1000 person-years). Bunches with higher CFPWV were related with a multivariable-adjusted 1.8-fold hazard of cardiovascular disease (P is less than 0.01) irrespective of AoR size in gender-pooled examinations. We noticed impact change by sex (P for sex×AoR-CFPWV group interaction is = 0.04). In men, the gathering with lesser aortic root diameter and higher CFPWV was related with a 2.5-to 2.8-fold hazard of CVD (P is less than 0.001). The gathering with bigger AoR and higher CFPWV encountered a genuinely nonsignificant 70% to 80% higher CVD hazard in females. Our perceptions show that the prognostic importance of a smaller against bigger aortic root diameter shifts in males versus females. Extra examinations are justified to affirm our discoveries.