Despite higher rates of diabetes (DM), hypertension (HTN), and hyperlipidemia (HLD) with increasing body mass index (BMI), a diagnosis of obesity was not associated with worse overall survival (OS) in women with breast cancer but being overweight was, suggesting the need for a more nuanced understanding of body composition, obesity-associated conditions, and their respective potential impact on breast cancer outcomes.

Women 18 years and older diagnosed with stage 0-IV breast cancer at an academic institution with known BMI at diagnosis were identified. χ2 and ANOVA tests were used to compare intergroup differences. BMI was categorized as normal, overweight, class 1 obesity, and class 2/3 obesity. Unadjusted OS by BMI class was estimated with the Kaplan-Meier method. Of patients included: 296 were overweight, 227 had class 1 obesity, and 207 had class 2/3 obesity. Non-Hispanic (NH) black women were overrepresented among obese patients, making up 25% of all patients but 37.5% of obese patients. Rates of DM, HTN, and HLD increased with increasing BMI. Unadjusted OS differed significantly by BMI class, with overweight women having the worst 5-year OS. After adjustment, BMI continued to be associated with OS, with overweight women having significantly worse OS vs normal-weight women, but there was no significant association between obesity and OS.

For latest news and updates

 

The effect of body mass index on survival in patients with breast cancer and obesity-associated conditions.