The use of aspirin in coronary artery disease and the unmet demand for aspirin therapy in individuals who have a history of hypersensitivity responses to aspirin or other nonsteroidal anti-inflammatory medications (NSAIDs). In 1.5 per cent of individuals with cardiovascular disease, aspirin hypersensitivity has been observed. Many individuals classified as allergic to aspirin, on the other hand, suffered adverse symptoms and could be treated safely with aspirin. Those who experienced genuine hypersensitivity responses were frequently not put on antiplatelet treatment. There are several techniques for aspirin desensitisation with various degrees of intricacy in the literature. The goal of this study is to identify the different forms of aspirin responses and to give a logical strategy to oral aspirin challenge and desensitisation.

In summary, with few exceptions, patients with a history of ‘aspirin/NSAID allergy’ who require ASA for cardiovascular problems will be able to safely take aspirin either after a graded challenge or desensitisation, highlighting the allergist’s essential role in these patients’ care.