CRSwNP is a heterogeneous inflammatory disease with multiple underlying etiologies. Although several CRSwNP endotypes have been detailed, the current classification system does not adequately represent all patients with nasal polyps. The conclusions described two patients meeting established diagnostic criteria for both AERD and AFRS, which are considered distinct CRSwNP endotypes.
Researchers did this study to describe patients meeting established diagnostic criteria for both AERD and AFRS to highlight deficits in the current CRSwNP endotype classification system and expand awareness of the potential for aspirin desensitization.
Patients met established diagnostic criteria for both AERD and AFRS. Microscopic examination of sinus tissue revealed reactive bone, tissue eosinophilia, and allergic mucin with noninvasive fungal elements. Subjects had an average of four endoscopic sinus surgeries and are currently maintained with adjunctive aspirin desensitization and anti-IL-5 biologic therapy.
This case series concluded that although they are treated as distinct CRSwNP endotypes, AERD and AFRS may have more overlap than was previously appreciated. Further research is needed to accurately identify discrete endotypes and associated treatment outcomes as we seek individualized patient care.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892420903587
