Recent injectable combination male contraceptive trial was terminated early due to AEs the study was done to check the associated factors.

Reported AEs by male research participants compared with AEs reported in prescribing information of approved female hormonal contraceptive methods. Published data from trials of the top five most-used female hormonal contraceptives, supplemented by contemporary contraceptive research, were compared with the frequency of AEs reported in a male injectable hormonal contraceptive trial.

Similar frequencies were observed of AEs reported by users of male contraceptives compared with those reported by female users. Women reported experiencing higher frequencies of headaches, pelvic pain, and weight gain and similar frequencies of decreased libido.

The study concluded through its findings that female hormonal methods generally have similar frequencies of AEs to those reported in a recent male hormonal contraceptive trial, and male users had lower rates of discontinuation due to AEs. There were fewer serious AEs of the male contraceptive than reported in contemporary female trials which resulted in FDA licensure. This suggests there may be implicit bias in the scientific community regarding the level of acceptable risk for users of male contraceptive methods.