The goal of this study was to use automated edge-detection software to measure endothelium dysfunction in the acute and convalescent stages of Kawasaki disease (KD). Case-control research was conducted to evaluate the flow-mediated dilatation (FMD) of the brachial artery (BA) in patients with KD during the acute phase and for at least 3 months following diagnosis. The pictures were captured using a 10-MHz multifrequency linear array probe connected to a high-resolution ultrasound machine. BA diameter was measured using automated edge detecting software. In the research, 16 children with KD and 16 healthy children participated. When comparing the acute stage of KD to the convalescence phase and healthy controls, the mean SD maximum BA diameter was found to be substantially lower during the acute period. The mean SD % change in FMD in the acute phase of KD was found to be substantially lower than in the convalescence phase of KD and healthy controls.
When compared to normal healthy youngsters, the FMD of the BA is considerably reduced in patients during the acute and convalescent phases of KD. Even in individuals who had no apparent coronary artery anomalies during the acute period, endothelial dysfunction was present.
