Despite extensive study on asthma, the association between 25-Hydroxy Vitamin D and asthma remains uncertain. This study was done to explore the associations of 25(OH) vit. D levels with asthma and with the severity of asthma were evaluated.
This was a case-control study that included 520 children that fulfilled the inclusion criteria for the study. Children with asthma were classified as cases and children who were referred for reasons other than respiratory problems and asthma were considered as controls. Serum 25 (OH) vit. D levels were then examined and compared.
260 asthmatic children and 260 controls participated in the present study. The mean 25 (OH) vit. D levels difference was statistically significant. 25(OH) vit. D levels were found to be 28.05 ± 16.98 in non-severe asthma and 21.41 ± 15.20 in severe asthma. 25(OH) vit. D level was negatively correlated with asthma severity.
The study concluded through its findings that the lower level of 25(OH) vit. D correlated with the higher severity of asthma manifestations. 25(OH) vit. D levels should be routinely checked especially in severe asthma cases and if the deficiency presents, appropriate therapeutic measures are used to reduce the asthma severity.
Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-020-00122-9
