In an official American Thoracic Society clinical practice guideline, published in the American Journal of Respiratory and Critical Care Medicine, recommendations are presented for the use of home oxygen therapy for adults with chronic lung disease. The authors created six research questions relating to delivery of home oxygen therapy to appropriate patients with COPD and interstitial lung disease (ILD). They found that the quality and availability of the evidence varied. For patients with COPD with severe chronic resting room air hypoxemia, long-term oxygen therapy (LTOT) is strongly recommended (moderate-quality evidence); LTOT is not suggested for adults with COPD with moderate chronic resting room air hypoxemia. Ambulatory oxygen is suggested for adults with COPD with severe exertional room air hypoxemia. For adults with ILD, LTOT is strongly recommended for those with severe chronic resting room air hypoxemia, while ambulatory oxygen is suggested for those with severe exertional room air hypoxemia (very low-quality and low-quality evidence, respectively). Portable liquid oxygen is suggested for patients with chronic lung disease who are mobile outside the house and require continuous oxygen fl ow rates greater than 3 L/ min during exertion. Patients prescribed home oxygen therapy and their caregivers should receive instruction and training on use and maintenance of oxygen equipment and oxygen safety. “We urge the research community and funding agencies to work together to develop a stronger evidence base that will guide clinical practice for oxygen prescription,” the authors write.”
January 8, 2021
The Efficacy and Safety of Hydroxychloroquine in Patients with COVID-19: A Multicenter National Retrospective Cohort.
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