Here are what the editors at HealthDay consider to be the most important developments in Pathology for August 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Medical Bills in Collections Decrease With Patient Age

FRIDAY, Aug. 31, 2018 (HealthDay News) — Medical collections decrease substantially with age, possibly because of increased health insurance coverage and incomes, according to a study published in the August issue of Health Affairs.

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An Allergy to Red Meat May Be Tied to Heart Disease

FRIDAY, Aug. 31, 2018 (HealthDay News) — An allergen in red meat may be tied to heart disease, according to a study published in the July issue of Arteriosclerosis, Thrombosis, and Vascular Biology.

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Ibudilast Appears to Slow Brain Atrophy Progression in MS

FRIDAY, Aug. 31, 2018 (HealthDay News) — In patients with progressive multiple sclerosis, slower progression of brain atrophy was seen with ibudilast versus placebo, according to a phase 2 trial published in the Aug. 30 issue of the New England Journal of Medicine.

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China Withholding H7N9 Bird Flu Virus Samples From U.S.

THURSDAY, Aug. 30, 2018 (HealthDay News) — Chinese officials have not sent lab samples of H7N9 bird flu virus to their U.S. counterparts despite repeated requests and an international agreement.

The New York Times Article

No Meaningful Increase in Physician Compensation Last Year

THURSDAY, Aug. 30, 2018 (HealthDay News) — There was no meaningful increase in physician compensation in 2017, and a decline in productivity was noted, according to the results of a survey conducted by AMGA Consulting.

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Marketplace Premiums Increase More With Monopolist Insurers

WEDNESDAY, Aug. 29, 2018 (HealthDay News) — Affordable Care Act Marketplace premiums increase more in areas with monopolist insurers, according to a study published in the August issue of Health Affairs.

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Chronic Vaping Exerts Biological Effects on Lungs

WEDNESDAY, Aug. 29, 2018 (HealthDay News) — Chronic vaping exerts biological effects on the lung, some of which may be mediated by the propylene glycol/vegetable glycerin (PG/VG) base, according to a study published in the July 1 issue of the American Journal of Respiratory and Critical Care Medicine.

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Medical Practices Should Address Negative Online Reviews

TUESDAY, Aug. 28, 2018 (HealthDay News) — Medical practice staff can effectively handle negative online reviews by staying calm and positive, looking for solutions, apologizing, and thanking the reviewers, according to an article published in Physicians Practice.

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Artificial Intelligence Holds Promise in Medicine

TUESDAY, Aug. 28, 2018 (HealthDay News) — Artificial intelligence (AI) in health care offers opportunities for early detection and triage, diagnostics and personalized medicine, and medical decision-making, according to an article published in Managed Healthcare Executive.

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Cardiovascular Health Tied to Brain Function in Younger Adults

TUESDAY, Aug. 28, 2018 (HealthDay News) — Having a greater number of modifiable cardiovascular risk factors at recommended levels is associated with higher cerebral vessel density and caliber, higher cerebral blood flow, and fewer white matter hyperintensities among young adults without clinical evidence of cerebrovascular disease, according to a study published in the Aug. 21 issue of the Journal of the American Heart Association.

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Retinal Abnormalities May Indicate Preclinical Alzheimer’s

TUESDAY, Aug. 28, 2018 (HealthDay News) — Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer’s disease (AD), according to a study published online Aug. 23 in JAMA Ophthalmology.

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Alcohol Is Leading Risk Factor for Global Disease Burden

TUESDAY, Aug. 28, 2018 (HealthDay News) — Globally, alcohol use is a leading risk factor for disease burden, according to research published online Aug. 23 in The Lancet.

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Experts Address Loss of the National Guideline Clearinghouse

TUESDAY, Aug. 28, 2018 (HealthDay News) — The demise of the National Guideline Clearinghouse (NGC) in July 2018 is likely to impact evidence-based health care around the world, according to an Ideas and Opinions piece published online Aug. 28 in the Annals of Internal Medicine.

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Two Ebola Patients Who Received Experimental Tx Have Recovered

MONDAY, Aug. 27, 2018 (HealthDay News) — Two of the first 10 people to receive an experimental Ebola treatment have recovered from the highly dangerous disease, Congo’s health ministry says.

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Sensor Array May Detect De Novo Parkinson’s Disease in Breath

MONDAY, Aug. 27, 2018 (HealthDay News) — A sensor array has the potential to identify de novo Parkinson’s disease (PD) patients with high sensitivity, specificity, and accuracy values, according to a research letter published online July 10 in ACS Chemical Neuroscience.

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Most Research Participants Not Concerned About Data Sharing

MONDAY, Aug. 27, 2018 (HealthDay News) — Few participants in clinical trials have strong concerns about the risks of data sharing, according to a special article recently published in the New England Journal of Medicine.

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AMA Adopts Policy Promoting Health Equity As a Goal

FRIDAY, Aug. 24, 2018 (HealthDay News) — The American Medical Association (AMA) House of Delegates has adopted a policy that sets health equity as a goal for the U.S. health care system, according to a report published in the organization’s AMA Wire.

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FDA: Illnesses Linked to McDonald’s Salads Reach 507

FRIDAY, Aug. 24, 2018 (HealthDay News) — The number of confirmed cases of Cyclospora infection linked to salads from McDonald’s restaurants was 507 in 15 states and New York City as of Aug. 23, according to the U.S. Food and Drug Administration.

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1997 to 2015 Saw Increase in HIV Viral Suppression Rates

THURSDAY, Aug. 23, 2018 (HealthDay News) — From 1997 to 2015 there was a considerable increase in HIV viral suppression rates among people living with HIV (PLWH), according to a study published online Aug. 21 in the Annals of Internal Medicine.

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Information Lacking on Effect of Prenatal Use of Marijuana

THURSDAY, Aug. 23, 2018 (HealthDay News) — More information is needed on marijuana use in pregnancy, according to an Ideas and Opinions piece published online Aug. 21 in the Annals of Internal Medicine.

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Small Practices Also at Risk for Data Breaches

WEDNESDAY, Aug. 22, 2018 (HealthDay News) — Data breaches can happen to small medical practices, but staff can take steps to prevent them, according to an article published in Medical Economics.

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4 Experimental Ebola Therapies Approved for Use in Congo

WEDNESDAY, Aug. 22, 2018 (HealthDay News) — Four more experimental treatments for Ebola virus have been approved by the Congo health ministry for use in an outbreak of the deadly infectious disease in the country’s northeast.

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Strategy Outlined for Shooter Incident in Health Care Facility

WEDNESDAY, Aug. 22, 2018 (HealthDay News) — Adhering to a “secure, preserve, fight” strategy is recommended for health care professionals working with a vulnerable patient population, according to a Medicine and Society piece published in the Aug. 9 issue of the New England Journal of Medicine.

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National Provider Identifiers Are Vulnerable to Theft

WEDNESDAY, Aug. 22, 2018 (HealthDay News) — National Provider Identifiers (NPIs) are vulnerable to identity theft, according to an article published in Physicians Practice.

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Similar Outcomes for Rural, Urban Cancer Patients in SWOG Trials

WEDNESDAY, Aug. 22, 2018 (HealthDay News) — Rural and urban cancer patients with uniform care access through participation in a SWOG (formerly the Southwest Oncology Group) treatment trial have similar outcomes, according to a study published online Aug. 17 in JAMA Network Open.

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Advantages for HDHP Enrollees in Large Versus Small Firms

WEDNESDAY, Aug. 22, 2018 (HealthDay News) — Workers in small firms are more likely to have higher deductible levels and lack employer contributions to help pay for out-of-pocket expenses compared to workers in larger firms, according to a study published in the August issue of Health Affairs.

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Doctors Often Not Discussing Risk Factors With Patients

TUESDAY, Aug. 21, 2018 (HealthDay News) — Patients report that doctors are routinely not discussing known risk factors for common causes of death, according to a survey conducted by ImagineMD.

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USPSTF Updates Guidance for Cervical Cancer Screening

TUESDAY, Aug. 21, 2018 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) has updated the recommendations for screening for cervical cancer; the final recommendation statement has been published in the Aug. 21 issue of the Journal of the American Medical Association.

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Plan to Relax Coal-Fired Power Plant Rules Could Up Mortality

TUESDAY, Aug. 21, 2018 (HealthDay News) — The Trump administration’s plan to relax pollution rules for coal-fired power plants will increase carbon emissions and cause up to 1,400 premature deaths a year, according to details released Tuesday.

The New York Times Article
EPA News Release

Pennsylvania Case Could Affect Evidence for Malpractice Defense

TUESDAY, Aug. 21, 2018 (HealthDay News) — The Pennsylvania Supreme Court has agreed to hear a case that could affect what evidence physicians may present in defense during medical malpractice suits, according to an article published in the American Medical Association’s AMA Wire.

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Large Number of Presumed Sudden Cardiac Deaths Are Not

TUESDAY, Aug. 21, 2018 (HealthDay News) — A large percentage of deaths attributed to cardiac arrest are neither sudden nor unexpected, according to a study published recently in Circulation.

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Experts Offer Tips for Provider Appeal of Denied Medical Claims

MONDAY, Aug.20, 2018 (HealthDay News) — Knowing payer policies and regulatory requirements is critical to appealing denials, according to an article published in Medical Economics.

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NYU Becomes First Medical School to Cover All Tuition

MONDAY, Aug. 20, 2018 (HealthDay News) — The NYU School of Medicine has announced that it is offering full-tuition scholarships to all current and future students in its M.D. degree program, regardless of need or merit.

Press Release

Review Addresses Cell-Free DNA Sequencing in Pregnancy

MONDAY, Aug. 20, 2018 (HealthDay News) — Cell-free DNA (cfDNA) sequencing represents an advance in genomic medicine and has associated ethical challenges, according to a review article published in the Aug. 2 issue of the New England Journal of Medicine.

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Comments Open on End of NIH Review for Gene Therapy Studies

FRIDAY, Aug. 17, 2018 (HealthDay News) — A U.S. National Institutes of Health oversight panel will no longer review all applications for gene therapy experiments. Instead, the panel will assume an advisory role, while the U.S. Food and Drug Administration will assess gene therapy experiments and products as it does with other treatments and drugs. The proposed change will take effect after a public comment period which runs through Oct. 16.

AP News Article
NIH Statement
Comment on Regulations

E-Cigarette Vapor Condensate Toxic to Alveolar Macrophages

FRIDAY, Aug. 17, 2018 (HealthDay News) — Electronic cigarette (e-cigarette) vapor condensate (ECVC) is significantly more toxic to alveolar macrophages than e-cigarette liquid (ECL), according to a study published online Aug. 13 in Thorax.

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Residents’ Sleep Deteriorates During Training

FRIDAY, Aug. 17, 2018 (HealthDay News) — First-year residents experience worsening sleep duration and quality as well as daytime sleepiness, according to a study published in the June issue of the Journal of General Internal Medicine.

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CDC: Brucellosis in Dogs Remains a Public Health Risk

THURSDAY, Aug. 16, 2018 (HealthDay News) — Brucella canis is an under-recognized infection in dogs that poses a threat to human health, according to a report published in the August issue of the U.S. Centers for Disease Control and Prevention’s Emerging Infectious Diseases.

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NIH Panel Will No Longer Review Gene Therapy Experiments

THURSDAY, Aug. 16, 2018 (HealthDay News) — A U.S. National Institutes of Health oversight panel will no longer review all applications for gene therapy experiments, according to a perspective piece published online Aug. 15 in the New England Journal of Medicine.

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Patient Portals Don’t Appear to Have Much Traction

THURSDAY, Aug. 16, 2018 (HealthDay News) — Patient portals have not taken off as expected, according to an article published in Medical Economics.

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ACA Coverage Gains Include Workers Without Insurance

THURSDAY, Aug. 16, 2018 (HealthDay News) — After the expanded coverage provisions of the Affordable Care Act (ACA) were implemented in 2014, self-employed individuals and wage earners without employer-sponsored health coverage offers had coverage gains equal to or greater than those of people not employed, according to a report published in the August issue of Health Affairs.

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Ancient Gene Protects Elephants From Cancer

WEDNESDAY, Aug. 15, 2018 (HealthDay News) — An ancient gene that protects elephants against cancer has been pinpointed and could lead to new ways to treat cancer in people, according to research published in the Aug. 14 issue of Cell Reports.

The New York Times Article
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cfDNA Screening First for Trisomy 21 Doesn’t Cut Miscarriage Rate

WEDNESDAY, Aug. 15, 2018 (HealthDay News) — Offering cell-free DNA (cfDNA) screening followed by invasive testing in the case of positive results does not result in a significant reduction in miscarriage among women with pregnancies at high risk of trisomy 21, according to a study published in the Aug. 14 issue of the Journal of the American Medical Association.

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Broad Genetic Testing for NSCLC May Not Improve Survival

WEDNESDAY, Aug. 15, 2018 (HealthDay News) — Broad-based genomic sequencing does not improve survival compared to routine genetic testing among patients with advanced non-small-cell lung cancer (NSCLC), according to a study published in the Aug. 7 issue of the Journal of the American Medical Association.

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Most Postmenopausal Bleeding Not Associated With Cancer

TUESDAY, Aug. 14, 2018 (HealthDay News) — Most women with postmenopausal bleeding (PMB) will not be diagnosed with endometrial cancer, according to a review published online Aug. 6 in JAMA Internal Medicine.

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Many Sexual Assault Victims Don’t Complete Evidence Kits

TUESDAY, Aug. 14, 2018 (HealthDay News) — Even with access to specialized forensic evidence collection, many sexual assault survivors do not complete a Sexual Assault Evidence Kit (SAEK), and even fewer release the evidence to police for investigation, according to a study published online Aug. 8 in the Emergency Medicine Journal.

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6 Factors Related to Inclusion in Health Care Workplace ID’d

TUESDAY, Aug. 14, 2018 (HealthDay News) — There are six broad factors that can affect inclusion within health care organizations, according to a study published online Aug. 3 in JAMA Network Open.

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Four Pros to Integrating EHR, Practice Management Software

MONDAY, Aug. 13, 2018 (HealthDay News) — Consolidating electronic health records and practice management software allows practices to save time and money, make fewer mistakes, and reduce the risk of privacy breaches, according to an article published in Physicians Practice.

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CDC: More Than 400 Sickened by McDonald’s Salads

MONDAY, Aug. 13, 2018 (HealthDay News) — The number of confirmed cases of a parasite-caused illness linked to McDonald’s Fresh Express Salad Mix is now 436 in 15 states, the U.S. Centers for Disease Control and Prevention says.

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Jury Awards $289 Million in Case Linking Roundup to Man’s Cancer

MONDAY, Aug. 13, 2018 (HealthDay News) — A $289 million award against Monsanto in a case linking its Roundup week killer to terminal cancer in a former school groundskeeper may lead to similar judgments against the company, according to the man’s lawyers.

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Neurodevelopmental Anomalies, Birth Defects Linked to Zika ID’d

MONDAY, Aug. 13, 2018 (HealthDay News) — Many children of mothers with evidence of confirmed or possible Zika virus infection during pregnancy do not undergo all recommended evaluations, according to a Vital Signs report published in the Aug. 10 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Court Rules That U.S. Must Halt Sales of Pesticide Chlorpyrifos

FRIDAY, Aug. 10, 2018 (HealthDay News) — The Environmental Protection Agency must remove the pesticide chlorpyrifos from sale in the United States within 60 days, a federal appeals court ordered yesterday.

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Will Lunar and Planet Dust Be Health Concerns of the Future?

FRIDAY, Aug. 10, 2018 (HealthDay News) — Dust could pose a health hazard if astronauts start spending extended periods of time on the Moon, Mars, or other airless planets, according to a study published recently in GeoHealth.

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AMA Adopts Policy on Augmented Intelligence

FRIDAY, Aug. 10, 2018 (HealthDay News) — The American Medical Association (AMA) House of Delegates has adopted a policy on augmented intelligence, according to a report published in the association’s AMA Wire.

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AMA Adopts Policy to Advance Gender Equity in Medicine

THURSDAY, Aug. 9, 2018 (HealthDay News) — The American Medical Association (AMA) House of Delegates has adopted a new policy to study, act for, and advocate to advance gender equity in medicine, according to a report published in the association’s AMA Wire.

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Vaccinations Begin in Congo Ebola Outbreak

THURSDAY, Aug. 9, 2018 (HealthDay News) — Vaccinations against Ebola began yesterday in an effort to stem the latest outbreak in Congo.

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Steps Taken to Increase Use of Electronic Tools in Medicine

WEDNESDAY, Aug. 8, 2018 (HealthDay News) — Additional codes have been approved by the Current Procedural Terminology (CPT) Editorial Panel for chronic care remote physiologic monitoring and internet consultations, according to a report published by the American Medical Association (AMA).

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AMA Proposes Policy Opposing Medicaid ‘Lockout’ Provisions

TUESDAY, Aug. 7, 2018 (HealthDay News) — A new policy opposing lockout provisions that block Medicaid patients from the program for lengthy periods and instead supporting allowing patients to reapply immediately for redetermination was adopted by the American Medical Association (AMA) House of Delegates during the AMA’s annual meeting in Chicago, according to an article published in the association’s AMA Wire.

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‘Good’ Cholesterol May Not Be So in Postmenopausal Women

TUESDAY, Aug. 7, 2018 (HealthDay News) — Elevated high-density lipoprotein cholesterol (HDL-C) may not always be cardioprotective in postmenopausal women, according to a study published online July 19 in Arteriosclerosis, Thrombosis, and Vascular Biology.

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Excess Zinc in Muscles May Drive Cancer-Related Wasting

TUESDAY, Aug. 7, 2018 (HealthDay News) — ZRT- and IRT-like protein 14 (ZIP14) upregulation in skeletal muscles may play a role in cancer-related muscle loss, according to a study published online June 6 in Nature Medicine.

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Thyroid Dysfunction Linked to Gestational Diabetes

TUESDAY, Aug. 7, 2018 (HealthDay News) — Higher free triiodothyronine (fT3) levels, but not free thyroxine (fT4) or thyroid-stimulating hormone (TSH) levels, are associated with gestational diabetes mellitus (GDM), according to a study published in the July 1 issue of the Journal of Clinical Endocrinology & Metabolism.

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Postmortem Cardiac Implantable Device Interrogation Useful

TUESDAY, Aug. 7, 2018 (HealthDay News) — Postmortem cardiac implantable electronic device (CIED) interrogation can improve the accuracy of identification of the time and cause of death at forensic autopsy, according to a study published in the June 19 issue of Circulation.

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Disparities Remain in Prevalence of Cancer Screening Tests

TUESDAY, Aug. 7, 2018 (HealthDay News) — There are persistent disparities in recommended cancer screening tests among U.S. adults, particularly among the uninsured, according to a study published online July 26 in the U.S. Centers for Disease Control and Prevention’s Preventing Chronic Disease.

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Thirteen Confirmed Ebola Cases in Latest Congo Outbreak

MONDAY, Aug. 6, 2018 (HealthDay News) — The number of confirmed cases in a new Ebola outbreak in Congo has reached 13, including three deaths, the country’s health ministry said late Saturday. It also said there were 30 probable cases and 33 suspected cases, the Associated Press reported.

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Biomarker Panel May Improve Lung Cancer Risk Assessment

MONDAY, Aug. 6, 2018 (HealthDay News) — Biomarker-based risk profiling has the potential to improve lung cancer risk assessment, according to a study published online July 12 in JAMA Oncology.

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Plasma Copeptin More Accurate for Diabetes Insipidus Diagnosis

MONDAY, Aug. 6, 2018 (HealthDay News) — In patients with hypotonic polyuria, the direct measurement of hypertonic saline-stimulated plasma copeptin has better diagnostic accuracy than the water-deprivation test, according to a study published in the Aug. 2 issue of the New England Journal of Medicine.

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Some Bacteria Now More Tolerant of Alcohol-Based Sanitizers

FRIDAY, Aug. 3, 2018 (HealthDay News) — Some types of bacteria are developing tolerance of alcohol-based hand sanitizers used in hospitals, according to a study published in the Aug. 1 issue of Science Translational Medicine.

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Variation in Specialty Drug Coverage Across Health Plans

FRIDAY, Aug. 3, 2018 (HealthDay News) — There is considerable variation in specialty drug coverage across commercial health plans, according to a study published in the July issue of Health Affairs.

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Skin Appears to Be Key Pathway for Absorption of BBQ Fumes

FRIDAY, Aug. 3, 2018 (HealthDay News) — Dermal absorption is a more important pathway than inhalation for the intake of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs) during barbecuing, according to a study published recently in Environmental Science & Technology.

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Ciprofloxacin May Up Likelihood of Aortic Dissection, Rupture

FRIDAY, Aug. 3, 2018 (HealthDay News) — In a mouse model of moderate, sporadic aortic aneurysm and dissection (AAD), ciprofloxacin increases susceptibility to aortic dissection and rupture, according to a study published online July 25 in JAMA Surgery.

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Groups Urge CMS to Reconsider Suspending Risk Adjustment

FRIDAY, Aug. 3, 2018 (HealthDay News) — In a letter sent to Administrator Seema Verma of the Centers for Medicare & Medicaid Services (CMS), medical organizations are urging reconsideration of the decision to suspend payments to insurers as required under the Affordable Care Act’s risk-adjustment program.

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Health Affairs Announces Launch of New Three-Year Initiative

THURSDAY, Aug. 2, 2018 (HealthDay News) — A council on health care spending and value has been established by the journal Health Affairs.

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Three Financial Metrics Can Improve Practice Performance

THURSDAY, Aug. 2, 2018 (HealthDay News) — By understanding three indices and metrics, physicians can change the financial outcome of their medical practice, according to a report published in Medical Economics.

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NIH Releases Large-Scale Dataset of CT Images

THURSDAY, Aug. 2, 2018 (HealthDay News) — To help improve detection accuracy of lesions, the National Institutes of Health (NIH)’s Clinical Center has made available a large-scale dataset of 32,000 annotated lesions identified on computed tomography (CT) images.

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New Ebola Outbreak in Congo

THURSDAY, Aug. 2, 2018 (HealthDay News) — Just a week after being declared Ebola-free, the Democratic Republic of Congo said yesterday that a new outbreak of the deadly virus has killed at least 20 people.

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New York City 2013 Measles Outbreak Proved Costly

THURSDAY, Aug. 2, 2018 (HealthDay News) — Vaccine refusals and delays, particularly in young children, fueled a large measles outbreak following importation of a case into the United States, according to a study published online July 30 in JAMA Pediatrics.

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PET Imaging Can Measure Synaptic Loss From Alzheimer’s

THURSDAY, Aug. 2, 2018 (HealthDay News) — Positron emission tomographic (PET) imaging can directly measure synaptic loss with Alzheimer’s disease, according to a small study published online July 16 in JAMA Neurology.

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New Short-Term Health Plans Have Large Coverage Gaps

THURSDAY, Aug. 2, 2018 (HealthDay News) — There are large coverage gaps in short-term health plans that were approved Wednesday by the Trump administration, and are described by critics as “junk insurance.”

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TGFB1 Mutation Ups Radiation-Induced Breast Fibrosis Risk

THURSDAY, Aug. 2, 2018 (HealthDay News) — The C-509T allele in the promoter region of transforming growth factor β (TGFB1) is associated with radiation-induced breast fibrosis risk among patients with early-stage breast cancer, according to study published online July 19 in JAMA Oncology.

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National Guideline Clearinghouse Offline Due to Funding Cuts

WEDNESDAY, Aug. 1, 2018 (HealthDay News) — The National Guideline Clearinghouse (NGC) and National Quality Measures Clearinghouse (NQMC) websites were taken down on July 16 when funding for these federal databases ended, according to an announcement by the Agency for Healthcare Research and Quality (AHRQ).

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Evidence Exists for Persistence, Transmission of Ebola Virus

WEDNESDAY, Aug. 1, 2018 (HealthDay News) — There is evidence for persistence of Ebola virus and transmission from a persistently infected individual, according to case study published online July 23 in The Lancet Infectious Diseases.

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Nut Intake Reduces HbA1c Among Adults With T2DM

WEDNESDAY, Aug. 1, 2018 (HealthDay News) — Nut intake reduces hemoglobin A1c (HbA1c) among individuals with type 2 diabetes, according to a study published in the August issue of Diabetologia.

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