Fewer Older Men Assessed, Treated for Osteoporosis
Fewer older men than women, even with higher risk, undergo DXA screening, 25(OH)D measurement
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Fewer older men than women, even with higher risk, undergo DXA screening, 25(OH)D measurement
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Most common underlying causes of death in sepsis are solid and hematologic cancers, chronic heart disease
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Product works by delivering insulin under the skin at set or variable rates
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Therapeutics and clinical risk management 4(1) 245-59 Abstract This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials...
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Molecular neurodegeneration 2019 02 1514(1) 9 doi 10.1186/s13024-019-0310-z Abstract BACKGROUND A GC hexanucleotide repeat expansion in the noncoding region of C9orf72 is the major genetic cause of frontotemporal dementia and...
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Cell 2019 01 29() pii 10.1016/j.cell.2019.01.018 Abstract Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type...
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Nature communications 2019 02 1310(1) 722 doi 10.1038/s41467-019-08676-2 Abstract Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) to maintain genomic integrity. Recombinase recruited to the DSBs by the...
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The Journal of clinical investigation 2019 02 12() doi 10.1172/JCI96313 Abstract Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer...
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PeerJ 2019 02 057() e6273 doi 10.7717/peerj.6273 Abstract Background Low-carbohydrate, high-fat (LCHF) diets are useful for treating a range of health conditions, but there is little research evaluating the degree of...
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Genome biology 2019 02 1120(1) 30 doi 10.1186/s13059-019-1644-0 Abstract BACKGROUND Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene...
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eLife 2019 02 128() doi 10.7554/eLife.40811 Abstract Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show...
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Resuscitation 2014 06 0285(9) 1204-11 doi 10.1016/j.resuscitation.2014.04.029 Abstract Hypothermic cardiac arrest has high mortality and few known prognostic factors. We studied retrospectively 34 victims of accidental...
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Immunity 2019 01 23() pii 10.1016/j.immuni.2019.01.001 Abstract Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize...
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Journal of clinical medicine 2019 02 078(2) pii 10.3390/jcm8020207 Abstract The immune system acting via cancer immune-surveillance is considered a potential target for improving outcomes among some malignancies. The ability to...
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Gastroenterology 2019 02 06() pii 10.1053/j.gastro.2019.01.261 Abstract BACKGROUND & AIMS In a phase 3 trial (RESORCE), regorafenib increased overall survival compared with placebo in patients with hepatocellular carcinoma...
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Nature communications 2019 02 0810(1) 688 doi 10.1038/s41467-019-08405-9 Abstract Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of...
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Nature communications 2019 02 0810(1) 650 doi 10.1038/s41467-018-08247-x Abstract During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized...
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The journals of gerontology. Series A, Biological sciences and medical sciences 72(12) 1595-1606 doi 10.1093/gerona/glx089 Abstract Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took...
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Cell reports 26(6) 1598-1613.e8 pii 10.1016/j.celrep.2019.01.036 Abstract Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans. The flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein...
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Cell reports 26(6) 1544-1556.e8 pii 10.1016/j.celrep.2019.01.043 Abstract The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the...
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