CDC: Brucellosis in Dogs Remains a Public Health Risk
Infection is under-recognized, may remain a threat without stronger intervention measures
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Author: Janine Anthes
Doctors Remove Contact Lens Embedded in Eyelid for Years
Lens was encapsulated within the upper eyelid soft tissue since childhood eye trauma
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NIH Panel Will No Longer Review Gene Therapy Experiments
FDA will now assess gene therapy experiments and products as it does with other treatments, drugs
Read MoreA complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.
Nature communications 2018 07 189(1) 2794 doi 10.1038/s41467-018-05273-7 Abstract Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while...
Read MoreThe Brain-Gut-Microbiome Axis.
Cellular and molecular gastroenterology and hepatology 2018 04 126(2) 133-148 doi 10.1016/j.jcmgh.2018.04.003 Abstract Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis....
Read MoreThe influence of connective tissue growth factor on rabbit ligament injury repair.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2017 04 2825(4) 498-503 doi 10.1016/j.jsps.2017.04.013 Abstract OBJECTIVES The injured anterior cruciate ligament (ACL) is deemed...
Read MoreAbnormal RNA stability in amyotrophic lateral sclerosis.
Nature communications 2018 07 209(1) 2845 doi 10.1038/s41467-018-05049-z Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein...
Read MoreThe influence of connective tissue growth factor on rabbit ligament injury repair.
Bone & joint research 6(7) 399-404 doi 10.1302/2046-3758.67.BJR.2016-0255.R1 Abstract OBJECTIVES The injured anterior cruciate ligament (ACL) is thought to exhibit an impaired healing response, and attempts at surgical...
Read MoreDirect observation of DNA target searching and cleavage by CRISPR-Cas12a.
Nature communications 2018 07 179(1) 2777 doi 10.1038/s41467-018-05245-x Abstract Cas12a (also called Cpf1) is a representative type V-A CRISPR effector RNA-guided DNA endonuclease, which provides an alternative to type II...
Read MoreRADX Modulates RAD51 Activity to Control Replication Fork Protection.
Cell reports 24(3) 538-545 pii 10.1016/j.celrep.2018.06.061 Abstract RAD51 promotes homologous recombination repair (HR) of double-strand breaks and acts during DNA replication to facilitate fork reversal and protect nascent DNA...
Read MoreA Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest.
The New England journal of medicine 2018 07 18() doi 10.1056/NEJMoa1806842 Abstract Background Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on...
Read MoreUnexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
eLife 2018 07 137() doi 10.7554/eLife.37754 Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These...
Read MoreIn vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway.
PLoS biology 2018 07 1616(7) e2005840 doi 10.1371/journal.pbio.2005840 Abstract Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental...
Read MoreALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.
Cell reports 24(3) 630-641 pii 10.1016/j.celrep.2018.06.066 Abstract The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA...
Read MoreThe Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Cell 174(2) 497 pii 10.1016/j.cell.2018.06.051 Abstract
Read MoreCo-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.
Nature communications 2018 07 139(1) 2724 doi 10.1038/s41467-018-05072-0 Abstract Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here,...
Read MoreDNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells.
Genome biology 2018 07 1219(1) 88 doi 10.1186/s13059-018-1464-7 Abstract BACKGROUND DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases...
Read MoreThe Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression.
Molecular cell 2018 06 2871(1) 56-72.e4 pii 10.1016/j.molcel.2018.06.003 Abstract Chromatin remodeling complexes play essential roles in metazoan development through widespread control of gene expression, but the precise...
Read MoreDrinking Patterns in US Counties From 2002 to 2012.
American journal of public health 2015 04 23105(6) 1120-7 doi 10.2105/AJPH.2014.302313 Abstract OBJECTIVES We estimated the prevalence of any drinking and binge drinking from 2002 to 2012 and heavy drinking from 2005 to 2012 in...
Read MorePhysical and Mental Effects of Bathing: A Randomized Intervention Study.
Evidence-based complementary and alternative medicine : eCAM 2018 06 072018() 9521086 doi 10.1155/2018/9521086 Abstract Showering is the most common form of bathing worldwide. Whole-body immersion bathing in warm water (~40°C)...
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