The endocannabinoid framework has numerous impacts. Through associating with cannabinoid receptor type 1 and type 2, this framework can significantly influence illness movement. Already, we showed that actuated cannabinoid receptor type 2 (CB2) interceded kidney fibrosis. Be that as it may, the hidden instruments remain underdetermined. Here, we report that CB2 was upregulated transcendently in kidney rounded epithelial cells in one-sided urinary check and ischemia-reperfusion injury models in mice, and in patients with an assortment of kidney infections. CB2 articulation was firmly corresponded with the movement of kidney fibrosis and joined by the enactment of β-catenin. Besides, CB2 incited the arrangement of a β-arrestin 1/Src/β-catenin complex, which further set off the atomic movement of β-catenin and caused fibrotic injury. Brooding with XL-001, an opposite agonist to CB2, or knockdown of β-arrestin 1 restrained CB2-set off initiation of β-catenin and fibrotic injury. Prominently, CB2 potentiated Wnt1-incited β-arrestin 1/β-catenin enactment and expanded the pathogenesis of kidney fibrosis in mice with one-sided ischemia-reperfusion injury or folic corrosive initiated nephropathy. Knockdown of β-arrestin 1 restrained the CB2 agonist AM1241-actuated β-catenin enactment and kidney fibrosis. By advertiser arrangement examination, putative record factor restricting locales for T-cell factor/lymphoid enhancer factor were found in the advertiser districts of the CB2 quality paying little mind to the species.
Reference link- https://www.kidney-international.org/article/S0085-2538(20)31235-7/fulltext