The study aimed to evaluate associations of preoperative TT with the risk of PCA.

Researchers measured Basal TT levels in 726 consecutive PCA patients. The logistic regression model evaluated the association of TT and other clinical factors with aggressive PCA.

In univariate analysis, there was a significant association of basal TT with the risk of aggressive PCA and age, PSA, percentage of BPC, CT, and biopsy ISUP grade groups. The first excluded biopsy ISUP grading groups, and the second included biopsy ISUP grade group one revealed TT and all other variables. Elevated basal PSA more significant than 20 µg/dl was associated with the risk of aggressive PCA. Multivariate model II showed that basal TT levels maintain a positive association between aggressive PCA, whereas age, BPC, and clinical stage cT3 lost significance. In the final adjusted model, the level of risk of TT did not change from univariate analysis.

Elevated preoperative TT levels are associated with the risk of aggressive PCA in the surgical specimen. TT may identify patients at risk of aggressive PCA in the low and intermediate EAU risk classes.