This study investigated the biocompatibility and pharmacokinetics of the implant in a rabbit model.
Implants with and without TP were placed on both intact and demucosalized maxillary sinuses of 33 New Zealand White rabbits. Sinuses with either intact or denuded bone without implants acted as controls.
Implants placed on intact mucosa or denuded bone were grossly integrated within 15 days. Minimal foreign body reaction was seen with negligible differences for inflammation, fibrosis, or bone remodeling among controls, sinuses with the implant, or sinuses with the implant plus TP, at all time points. However, the denuded bone controls demonstrated a more significant percentage of reepithelialization at five days compared with denuded bone with the implant or implant plus TP. Plasma concentrations of TP were generally deficient and were undetectable after day 7.
The study concluded that implant and the implant plus TP seemed to be biocompatible in rabbits. The implant plus TP effectively eluted steroid locally over at least 44 days, with negligible plasma concentrations. Further studies are warranted regarding potential therapeutic applications in patients undergoing ESS for chronic rhinosinusitis.
Reference: https://journals.sagepub.com/doi/full/10.2500/ajra.2017.31.4481
