The goal of this paper is to summarise current information about mediators involved in anaphylactic responses, with a particular emphasis on important effector cells and processes. Other pathways, such as the involvement of cytokines, platelet activation factor, lipid mediators and their metabolism, or contact system activation, have revealed new insights into their potential importance.

Researchers will be able to explore the discovery of risk variables as well as new preventative and therapeutic techniques in anaphylaxis if they have a better understanding of these pathophysiologic processes.