There is a correlation between sickle cell disease (SCD) and an increased risk of cardiovascular disease, which may be caused by a number of different risk factors, one of which is irregular blood pressure. It has been found that the blood pressure (BP) of children and adolescents who suffer from SCD is lower than the BP of the overall pediatric population. Researchers compared the reference blood pressure levels of children with SCD to the reference blood pressure values of the general pediatric population to validate this earlier observation. Their working hypothesis was that children diagnosed with SCD do not have a significantly lower blood pressure than children who do not have SCD. The systolic blood pressure of males and females of different age groups and of pediatric participants with and without SCD was shown to be significantly different. In both obese and non-obese groups, systolic blood pressure was greater in children with SCD. There was no significant difference in the groups’ diastolic blood pressure. According to the findings of this study, the average systolic blood pressure of children with SCD is much greater than that of the general pediatric population. This finding is in line with the most recent research that found aberrant blood pressure patterns in the pediatric population of SCD patients who used devices that monitored their BP continuously for 24 hours. This is a crucial stage in the process of identifying high blood pressure as a risk factor for cardiovascular and neurovascular events in SCD patients.