Anaphylaxis is a potentially lethal condition in which the cardiovascular system is responsible for the bulk of clinical symptoms. For this study, the most recent clinical and experimental findings on cardiovascular involvement during anaphylaxis have been summarized. In recent years, significant efforts have been undertaken to better understand the pathophysiology of anaphylactic reactions and to identify risk factors for the development of this reaction. During anaphylaxis, coronary blood flow might be reduced, which can greatly contribute to a poor result. Pre-existing coronary artery disease is also a risk factor for anaphylaxis. Furthermore, acute ischemia events such as angina and myocardial infarction are now considered part of the clinical picture of anaphylaxis. Furthermore, cardiac emergencies might manifest as the clinical picture of mast cell-related illnesses. Cardiovascular and allergy disorders are both common in communities. Greater knowledge of the processes that contribute to cardiac mast cell activation and the impact of mast cell mediators on the circulatory system will aid enhance anaphylaxis prevention and therapy.