For a study, researchers sought to understand that the palms, soles, and nasolabial folds commonly have a yellowish tint. Even when a condition is harmless and safe, bodily symptoms may still be present. Carotenoderma has distinct symptoms that make it easy to recognize even though the cause was still unknown. Investigators described a very unusual instance of lycopenemia brought on by consuming an excessive amount of lycopene-rich fruits and vegetables, which resulted in carotenoderma. Lycopene, a carotenoid component, was renowned for its extraordinary ability to absorb light at wavelengths of about 488 nm. Given these traits, they used fluorescence microscopy with 488 nm wavelength emission to investigate a hematoxylin-eosin-stained patient specimen as well as tape-stripped samples, and they contrasted them with normal skin samples. Notably, the patient samples revealed less autofluorescence in the sweat glands and stratum corneum. Additionally, when they used Vegecheck® to measure the carotenoid concentrations in the patient’s skin noninvasively, they discovered a higher score than the average of 24 healthy individuals. These findings supported the widely accepted theory that perspiration contains carotenoids that were later deposited in the stratum corneum. Study group was aware that no other publications had looked at the carotenoid levels in the skin or talked about the pathological effects that carotenoderma patients experience. This case demonstrated how a diet high in lycopene promotes carotenoderma and that the stratum corneum of the epidermis was where the carotenoid deposition was most conspicuous.