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Asthma

Immunomodulatory Effect of SINA 1.2 Therapy Protocol in Asthmatic Mice Model: A Combination of Oxymel and Sauna.

May 02, 2022

Alternative medicine, has become popular in asthmatic patients. We evaluated the immunomodulatory effects of SINA 1.2 therapy protocol derived from Persian medicine in an asthmatic mice model. Forty-t...

Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness.

Apr 18, 2022

S100A11 is a member of the S100 calcium-binding protein family and has intracellular and extracellular regulatory activities. We previously reported that S100A11 was differentially expressed in the re...

Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis.

Apr 18, 2022

Bronchial asthma poses a considerable burden on both individual patients and public health. Sesamin is a natural lignan that relieves asthma. However, the potential regulatory mechanism has not been f...

Telemedicine & Self-Administered Therapy for Severe Asthma

Apr 14, 2022

Clinicians should consider extending telemedicine in routine clinical practice to manage severe asthma, as well as other chronic respiratory diseases. Research has shown that patients with seve...

Assessing socioeconomic bias in machine learning algorithms in health care: a case study of the HOUSES index.

Apr 11, 2022

Artificial intelligence (AI) models may propagate harmful biases in performance and hence negatively affect the underserved. We aimed to assess the degree to which data quality of electronic health re...

[Cetirizine inhibits activation of JAK2-STAT3 pathway and mast cell activation in lung tissue of asthmatic mice].

Apr 04, 2022

Objective To investigate the effects of cetirizine on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and mast cell activation in asthmatic mice by establishing ...

Exploring the Potential Effects and Mechanisms of Radix Essential Oil for Treatment of Asthma.

Mar 28, 2022

Asthma, a common chronic pulmonary disorder characterized by airway remodeling, hyperresponsiveness and obstruction, can be aggravated by repeated exposure to particulate matter (PM). The potential ef...

Effect of Houpo-Mahuang Decoction on aggravated asthma induced by cigarette smoke and the expression of TRPA1 and tight junctions in mice.

Mar 28, 2022

Cigarette smoke (CS) is a common environmental irritant and a risk factor for asthma, as it induces as well as aggravates asthmatic attacks. The injured airway epithelial tight junctions (TJs) aggrava...

Lacticaseibacillus rhamnosus modulates the inflammatory response and the subsequent lung damage in a murine model of acute lung inflammation.

Mar 21, 2022

The present study investigated the anti-inflammatory effect of the probiotic Lacticaseibacillus rhamnosus (Lr) on lung inflammation induced by Lipopolysaccharide (LPS) of Escherichia coli in C57BL/6 ...

MicroRNA-98-5p Inhibits IL-13-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells by Targeting RAC1.

Mar 21, 2022

The dysfunction of airway smooth muscle cells (ASMCs) is one of the key factors in the pathogenesis of asthma. How miR-98-5p works in asthma has not been completely elucidated. This work focused on ho...

Exploring the Role of Social Determinants in Asthma & Eczema

Mar 14, 2022

Social determinants of health such as low income, costs, disease severity, and insurance status contribute to asthma and eczema disparities and may drive higher hospitalization rates in marginalized m...

Changes after 12 years of follow-up severe asthma patients cohort: higher obstruction and comorbidities, but significant better quality of life.

Mar 14, 2022

The Brazilian Cohort of Asthma São Paulo (BRASASP) had a well-characterized severe asthmatic in Brazil, with 12 years of follow-up under standard treatment. Sequential assessment of patients with un...

Geographic Differences in Severe Uncontrolled Asthma Across the US

Mar 13, 2022

Epidemiologic data regarding the burden of asthma are inconsistent, though as many as a quarter to half of patients with severe uncontrolled asthma (SUA)—which is caused by exacerbations of the dise...

The effect of ma-Xin-Gan-Shi decoction on asthma exacerbated by respiratory syncytial virus through regulating TRPV1 channel.

Mar 07, 2022

The incidence and mortality of bronchial asthma are increasing, and RSV is widely regarded as the common cause of clinical exacerbation of asthma. Ma-Xing-Gan-Shi decoction (MXGSD), a classic traditio...

Real-world effectiveness of benralizumab: results from the ZEPHYR 1 Study.

Mar 07, 2022

Real-world evidence characterizing the clinical outcomes and economic impact on patients with severe eosinophilic asthma treated with benralizumab is limited.To characterize patients with severe asthm...

Respiratory pattern complexity in newly-diagnosed asthmatic patients.

Feb 28, 2022

The intensity of respiratory symptoms and expiratory airflow limitations in asthma fluctuate over time. Some studies have reported variable complexity of the respiratory patterns in asthmatic patients...

[Acupoint catgut embedment may reduce airway inflammation reaction by down-regulating ICAM-1 and EOS by suppressing p38MAPK signaling in lung tissue of asthmatic rats].

Feb 28, 2022

To observe the effect of acupoint catgut embedment(ACE) on expression of p38 mitogen activated protein kinase (p38MAPK), intercellular adhesion molecule-1(ICAM-1), interleukin-4 (IL-4) and eosinophils...

Therapeutics effects of inhaled magnesium sulfate combined with adrenergic beta-2 agonist on children with acute asthma: Systematic review and meta-analysis.

Feb 21, 2022

To review the evidence on the effectiveness of inhaled magnesium sulfate (MgSO4) combined with beta-2 (B2) agonist as compared to inhaled B2 agonist alone in treating pediatric patients with moderate ...

Synergistic Effect of Roflumilast with Dexamethasone in a Neutrophilic Asthma Mouse Model.

Feb 21, 2022

Asthma is a chronic airway inflammatory disease with heterogeneous features. Most cases of asthma are steroid sensitive, but 5-10% are unresponsive to steroids, leading to challenges in treatment. Neu...

Pharmacological screening of Acalypha indica L.: Possible role in the treatment of asthma.

Feb 14, 2022

Acalypha indica Linn (Euphorbiaceae), a popular traditional medicine, is an erect herb found throughout various parts of India. In Ayurveda, Acalypha indica was commonly used in asthma and allergy. Ho...