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Asthma

Association of Toll-like receptors 4 (TLR-4) gene expression and polymorphisms in patients with severe asthma.

Oct 11, 2021

Innate immunity plays a central role in the pathogenesis of severe asthma, and it is closely linked to elevated IgE and Toll-like receptor 4 (TLR-4) levels. However, there is a scarcity of information...

Management of chronic rhinosinusitis with nasal polyps in Samter triad by low-dose ASA desensitization or dupilumab.

Oct 11, 2021

Samter triad is a chronic condition where patients suffer from intolerance to aspirin, recurring nasal polyposis and bronchial asthma. Causative treatment is often hard. Potential approaches are the d...

Effect of insulin resistance on lung function in asthmatic children.

Oct 04, 2021

Insulin resistance may be associated with impaired lung function. The objective of this study was to examine the relationship between insulin resistance and lung function in asthmatic children.We perf...

Clinical and Immunological Evaluation of Cat-allergic Asthmatics Living With or Without a Cat.

Oct 04, 2021

Characterizing the clinical and immunological impact of daily cat exposure in cat-allergic subjects with asthma who live with cats (WC) and those who do not (WoC) may provide understanding of the driv...

Atypical asthma in children who present with isolated chest tightness: risk factors and clinical features.

Sep 27, 2021

Asthmatic children presenting with chest tightness as the only symptom have not been widely recognized. This study attempted to find risk factors, summarize clinical features and offer some suggestion...

EXERCISE-INDUCED BRONCHODILATION EQUALIZES EXERCISE VENTILATORY MECHANICS DESPITE VARIABLE BASELINE AIRWAY FUNCTION IN ASTHMA.

Sep 27, 2021

We quantified the magnitude of exercise-induced bronchodilation in adult asthmatics under conditions of narrowed and dilated airways. We then assessed the effect of the bronchodilation on ventilatory ...

Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitisation.

Sep 20, 2021

Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant.We aimed to see if...

SMART for the treatment of asthma: A network meta-analysis of real-world evidence.

Sep 20, 2021

A large proportion of asthmatic patients are treated with protocols resulting from data obtained by randomized controlled trials (RCTs) for which they would not have been eligible. Therefore, the aim ...

Asthma: Making the Case for Increasing the Focus on Health-Related Quality of Life

Sep 15, 2021

Each year in the United States, about 15.4 million people are treated for asthma, but the impact of the disease extends beyond medical care, absenteeism, and mortality. “People with severe asthma ar...

The Impacts of Severe Asthma on QOL & Productivity

Sep 13, 2021

“Asthma diagnosis and management are based on an unclear combination of subjective, symptom-based measurements (such as daytime and nighttime symptoms and activity impairment) and objective measurem...

GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma.

Sep 13, 2021

GLCCI1 plays a significant role in modulating glucocorticoid (GC) sensitivity in asthma. This project determines the underlying mechanism that GLCCI1 deficiency attenuates GC sensitivity in dexamethas...

Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes.

Sep 13, 2021

Asthma is a heterogeneous disease with distinct prevalence and manifestation between sexes. This study was to identify sex-specific features of asthma via metabolomic analysis of sphingolipids.Forty-t...

Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.

Sep 13, 2021

Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood. Here, we...

School Pest Management Program Significantly Reduced Asthma Symptoms in Kids

Sep 10, 2021

But improvements not sustained, waning later in the school year Neither a school-wide integrated pest management (IPM) program nor the placement of classroom HEPA filter purifiers reduced the number ...

[Anti-asthmatic effect of agarwood alcohol extract in mice and its mechanism].

Sep 06, 2021

As recorded, agarwood has the function of improving qi reception and relieving asthma, but the underlying mechanism is unclear and rarely reported. Therefore, this study explored the anti-asthmatic ef...

[Preparation of anti EGFR scFv::FTH1/FTH1 nanoparticles for asthma treatment].

Sep 06, 2021

Asthma is a common respiratory disease that affects 300 million of people worldwide, posing a serious health risk and medical burden. Development of new anti-asthmatic drugs and alternative treatment ...

Ultra-high-resolution computed tomography shows changes in the lungs related with airway hyperresponsiveness in a murine asthma model.

Sep 06, 2021

In vivo presentation of airway hyper-responsiveness (AHR) at the different time points of the allergic reaction is not clearly understood. The purpose of this study was to investigate how AHR manifest...

Frequency of Persistent Obesity 5 years After First Time Diagnosis of Status Asthmaticus.

Aug 30, 2021

When a severe asthma exacerbation occurs in an obese pediatric patient, it is unknown if this body type persists in future encounters. Persistent obesity can lead to future asthma exacerbations. The m...

IL-8 gene expression and bronchial asthma phenotypes in children.

Aug 30, 2021

Asthma is a common chronic illness among school children, where different cytokines, including IL-8 play a role in its pathogenesis. IL-8 induces chemotaxis and migration of immune cells, especially n...

Unusual longstanding intrabronchial foreign body masquerading as intractable bronchial asthma in an adult: Case report and literature review.

Aug 30, 2021

Tracheo-bronchial foreign body inhalation is a very common encounter in clinical practice among pediatric patients and rarely seen among adults. When inhalation of foreign bodies occurs in adults then...