Allergy & Immunology General | Physician's Weekly
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Allergy & Immunology General

Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity

Jul 27, 2021

Adjuvants have diverse, but often subtle, impacts on vaccination-induced immune responses that are important for vaccine effectiveness. In-depth profiling of vaccine-induced cytokine, cellular, and an...

Establishing amoxicillin allergy in children through direct graded oral challenge (GOC): evaluating risk factors for positive challenges, safety, and risk of cross reactivity to cephalosporines.

Jul 26, 2021

Data on the diagnostic properties of direct oral challenges without the use of skin tests in children with suspected amoxicillin allergy is sparse.Assess the use of direct oral challenges.A cohort stu...

A Systematic Review and Meta-Analysis of the Effect of Intraoperative Bupivacaine in Gynaecologic Surgery After 24 Hours or 9 Half-lives.

Jul 26, 2021

To review all high quality available evidence regarding the effect of intraoperative bupivacaine 24 hours (or 8.9 half-lives) after intraoperative administration at time of gynaecologic surgery and to...

Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling.

Jul 26, 2021

GITRL/GITR signaling pathway plays an important role in allergy, inflammation, transplantation and autoimmunity. However, its role in asthma remains unclear. Thus, the present study aimed to investiga...

The phenothiazine, trifluoperazine, is selectively lethal to ABCB1-expressing multidrug resistant cells.

Jul 22, 2021

P-glycoprotein, member of the B-subfamily of the ATP-binding cassette (ABC) superfamily (e.g., ABCB1), has been demonstrated to confer resistance to clinically relevant anticancer drugs. Paradoxically...

Brain volume change after high-dose immunosuppression and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis.

Jul 22, 2021

Brain volume loss (BVL) is commonly observed after high-dose immunosuppression and autologous hematopoietic cell transplantation (HDIT/HCT) for treatment of multiple sclerosis (MS). To better understa...

Eosinophilic Reaction at the Time of Catheter Insertion Predicts Survival in Patients Initiating Peritoneal Dialysis.

Jul 22, 2021

Despite excellent biocompatibility, insertion of silicone peritoneal dialysis (PD) catheters can induce minor foreign body reaction, affecting long-term patient outcomes. We evaluated the effect of eo...

Management of adverse reactions to first-line tuberculosis antibiotics

Jul 21, 2021

Tuberculosis (TB) is the most prevalent infectious cause of mortality worldwide. Adverse responses to first-line TB medicines are widespread and have a significant influence on patient outcomes since ...

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions

Jul 21, 2021

Although HLA linkages have been used to define susceptibility to allergic medication responses, other genetic and nongenetic variables are also likely to be involved. Polymorphic genetic variations in...

Mechanisms leading to T-cell activation in drug hypersensitivity

Jul 21, 2021

Drug-specific T lymphocytes are frequently activated in delayed-type or nonimmediate drug hypersensitivity responses. As a result, a contact between HLA proteins, HLA-binding peptides, and the medicat...

Interaction between foods and nonsteroidal anti-inflammatory drugs and exercise in the induction of anaphylaxis

Jul 21, 2021

To evaluate research focusing on the investigation of food-dependent exercise-induced anaphylaxis (FDEIA) and food-dependent NSAID-induced anaphylaxis (FDNIA). Exercise and nonsteroidal anti-inflammat...

The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol

Jul 21, 2021

The purpose of this review is to examine new findings that suggest paracetamol metabolism has a role in hypersensitivity responses to this medication. Recent advances in the identification of novel pa...

NSAIDs hypersensitivity: questions not resolved

Jul 21, 2021

NSAIDs are the most commonly implicated medications in hypersensitivity responses (HSR). HSR is a major problem that may impact people of any age. These medications can cause responses by activating t...

Vaccine rejection and hesitation in Turkey

Jul 21, 2021

Vaccination rejection has grown in Turkey in recent years, according to primary care providers. The current study sought to ascertain the incidence of vaccine rejection and hesitation in Turkey, as we...

Association of cognitive biases with human papillomavirus vaccine hesitancy

Jul 21, 2021

Given the relationship between vaccination hesitancy and vaccine-preventable disease outbreaks, it is essential to investigate the cognitive processes that lead to vaccine hesitancy development, parti...

Long-term immunogenicity and immune memory response to the hepatitis B antigen in the RTS,S/AS01E malaria vaccine

Jul 21, 2021

The RTS,S/AS01E malaria vaccine contains the hepatitis B virus surface antigen and so has the potential to act as a hepatitis B vaccine. To assess the effectiveness of RTS,S/AS01E in the Expanded Prog...

Routine infant vaccination of pneumococcal conjugate vaccines has decreased pneumonia

Jul 20, 2021

Pneumococcal conjugate vaccines (PCVs) have been demonstrated to be beneficial in the prevention of pneumonia and invasive pneumococcal infections since the early 2000s. The Galician area was the firs...

Development of a pseudovirus-based assay for measuring neutralizing antibodies against Coxsackievirus A10

Jul 20, 2021

Coxsackievirus A10 (CV-A10) has lately emerged as a significant pathogen of hand, foot, and mouth disease (HFMD) in children all over the world. There are currently no viable therapies; the developmen...

Analysis of the CD8+ IL-10+ T cell response elicited by vaccination with the oncogenic tumor-self protein D52

Jul 20, 2021

The development of cancer vaccines targeting tumour self-antigens is complex and difficult due to the difficulties of overcoming immune tolerance to self-proteins. Vaccination against the tumour self-...

Hypersensitivity reactions to beta-lactams in children

Jul 20, 2021

The purpose of this paper is to give the most recent information on beta-lactam hypersensitivity responses in children. When studying beta-lactam allergy in children, drug provocation tests (DPTs) rem...

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