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Pain General

Real world effectiveness and tolerability of candesartan in the treatment of migraine: a retrospective cohort study.

Feb 18, 2021

To date, two randomized, controlled studies support the use of candesartan for migraine prophylaxis but with limited external validity. We aim to evaluate the effectiveness and tolerability of candesa...

Muscle activity and acute stress in fibromyalgia.

Feb 18, 2021

Fibromyalgia (FM) patients are likely to differ from healthy controls in muscle activity and in reactivity to experimental stress.We compared psychophysiological reactivity to cognitive stress between...

Numeric Rating Scales Show Prolonged Post-exertional Symptoms After Orthostatic Testing of Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Feb 18, 2021

Muscle pain, fatigue, and concentration problems are common among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). These symptoms are commonly increased as part of the ph...

Trajectories of change in symptom severity in patients with fibromyalgia: exploratory analyses of a randomised controlled trial.

Feb 18, 2021

The clinical picture of fibromyalgia (FM) symptoms fluctuates, and the symptom severity varies within and between patients. The current study aimed to identify groups of PDS trajectories and to explor...

Inhibition of ERK1/2 Phosphorylation attenuates Spinal Cord Injury Induced Astrocyte Activation and Inflammation through Negatively regulating Aquaporin-4 in Rats.

Feb 18, 2021

The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects o...

Meta-analysis of outcomes after intentional coverage of celiac artery in thoracic endovascular aortic repair.

Feb 18, 2021

The aim of this study was to demonstrate clinical outcomes of intentional coverage of celiac artery (CA) during thoracic endovascular aneurysm repair (TEVAR).MEDLINE, EMBASE, and Cochrane Library were...

Bisphosphonates in inflammatory rheumatic diseases.

Feb 18, 2021

The main well recognized action of bisphosphonates (BPs) is their antiresorptive capacity, making them first-line drugs in the treatment of osteoporosis and other metabolic bone diseases. In this revi...

[EBV-positive MTX-associated lymphoproliferative disorder and Ig M myeloma in rheumatoid arthritis].

Feb 18, 2021

 An 80-year-old female patient arrived with a pronounced lymphadenopathy and weight loss. 6 years ago she had been diagnosed with rheumatoid arthritis. At the time of arrival, she was administered M...

Relationship between psychological factors and spinal motor behaviour in low back pain: a systematic review and meta-analysis.

Feb 18, 2021

This meta-analysis investigated whether more negative psychological factors are associated with less spinal amplitude of movement and higher trunk muscle activity in individuals with low back pain. Fu...

The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation.

Feb 18, 2021

Chronic pain is highly comorbid with affective disorders, including major depressive disorder. A core feature of major depressive disorder is a loss of interest in previously rewarding activities. Maj...

PAIN CATASTROPHIZING, OPIOID MISUSE, OPIOID USE, AND OPIOID DOSE IN PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN: A SYSTEMATIC REVIEW.

Feb 15, 2021

The objective of this study was to analyze the cross-sectional and longitudinal association between pain catastrophizing and opioid misuse, opioid use, and opioid dose in people with chronic musculosk...

A patient perspective of complementary and integrative medicine (CIM) for migraine treatment: a social media survey.

Feb 15, 2021

To survey persons with migraine who use social media about Complementary and Integrative Medicine (CIM) for the treatment of migraine.CIM encompasses medical treatments that are not part of but are us...

Pooled Analysis of PFO Occluder Device Trials in Patients With PFO and Migraine.

Feb 15, 2021

Although observational studies have shown percutaneous patent foramen ovale (PFO) closure to be a safe means of reducing the frequency and duration of migraine, randomized clinical trials have not met...

Discharge Opioid Prescription Patterns after Kidney Cancer Surgery.

Feb 11, 2021

To describe opioid prescribing patterns for patients undergoing kidney cancer surgery and evaluate associations with medical resource utilization in the postoperative setting.Linked Surveillance, Epid...

Is Opioid-Free Post-Vasectomy Analgesia a Pain? A Single Surgeon Experience.

Feb 11, 2021

To determine the impact of transitioning from opioid to non-opioid analgesia post-vasectomy on unplanned opioid prescriptions and health encounters.A retrospective review for patients who underwent va...

The Effect of Preoperative Opioid Education on Opioid Consumption After Outpatient Orthopedic Surgery: A Prospective Randomized Trial.

Feb 11, 2021

Pain management and opioid consumption following outpatient orthopedic surgery may be influenced by several variables, including knowledge of safe opioid use. A prospective randomized study was undert...

Genetics Influences Drug Consumption in Medication Overuse Headache, Not in Migraine: Evidence From Wolframin His611Arg Polymorphism Analysis.

Feb 11, 2021

The Wolframin His611Arg polymorphism can influence drug consumption in psychiatric patients with impulsive addictive behavior. This cross-sectional study aims to assess the prevalence of the Wolframi...

Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial.

Feb 11, 2021

The migraine-preventive drug propranolol is efficacious in reducing pain from temporomandibular disorder, suggesting potential modifying or mediating effects of comorbid migraine.In this randomized co...

Muscle endurance and cervical electromyographic activity during submaximal efforts in women with and without migraine.

Feb 11, 2021

Despite previous reports supporting cervical muscle weakness and altered motor control in migraine, the endurance under standardized submaximal loads has not been investigated. Therefore, this study a...

Pain Intensity and Sensory Perception of Tender Points in Female Patients with Fibromyalgia: A Pilot Study.

Feb 11, 2021

Fibromyalgia syndrome (FMS) is a condition that courses with chronic pain, fatigue, sleep disturbance, impaired quality of life and daily function. Due to the lack of blood, imaging or histological co...

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