For a study, researchers sought to assess the minimally clinically important difference (MCID) in patients receiving cervical disc replacement (CDR) for cervical spondylotic radiculopathy versus myeloradiculopathy across multiple patient-reported outcomes (PROs). Patients with radiculopathy versus myeloradiculopathy who underwent 1 or 2-level CDR were identified, and prospectively obtained data were examined. Demographic data, preoperative diagnostic, and surgical data were gathered for each patient. The following PROs were collected prospectively: Visual analog scale (VAS)-Neck, VAS-Arm, SF-12 Physical Component Score (PCS), SF-12 Mental Component Score (MCS), PROMIS Physical Function Score (PF). The percentage of patients reaching the MCID was compared between the 2 diagnosis groups after an MCID analysis of PROs was done for each diagnosis group. There were 85 patients, 56% of whom had radiculopathy, and 44% had myeloradiculopathy. The percentage of patients with radiculopathy or myeloradiculopathy achieving the MCID for each PRO evaluated did not differ significantly at 6-week, 12-week, or final postoperative follow-up, according to MCID analysis. Except for the SF-12 MCS in patients with myeloradiculopathy, the percentage of patients achieving the MCID for each PRO increased from the 6-week to final postoperative follow-up in both diagnostic groups. In the radiculopathy and myeloradiculopathy groups treated with CDR, the percentage of patients achieving the MCID was not statistically different at each postoperative period. Furthermore, for practically all PROs examined, the percentage of patients achieving the MCID increased from 6 weeks to final follow-up in both groups.