YNS is characterized by the triad of thickened yellow nails, primary lymphedema, and respiratory manifestations, including sinusitis. This study aims to describe the embodiments of CRS in patients with YNS and comorbid presentations.

A retrospective review of patients with YNS with CRS was conducted. Their symptoms, comorbidities, and labs were reviewed. The patient’s sinus CT scans were then scored using the LM scoring system.

Out of the total initial sample, only thirty-six patients met the inclusion criteria. The average LM score was 10.2 ± 0.5. Sinus involvement included “frothy” dependent sinus secretions in thirty-two of thirty-six subjects. The most common sinus involvement location was the maxillary sinuses, then posterior ethmoid, anterior ethmoid, sphenoid, and frontal sinuses. Comorbid chronic cough, bronchiectasis, lymphedema, and pleural effusion were also identified. Three patients had immunodeficiencies.

This most extensive series concluded that the sinus manifestations of CRS in patients with YNS. Sinus CT scans showed frothy dependent secretions in the maxillary sinuses and posterior ethmoid sinuses most commonly. YNS patients with sinusitis more widely presented with chronic cough or bronchiectasis than with pleural effusions or lymphedema.

Reference: https://journals.sagepub.com/doi/full/10.1177/1945892419881253