Adults and children with mental health issues who also have a chronic condition have increased medical care usage and expenses. Celiac disease (CD) is related to a greater incidence of psychopathology in adults and has a significant perceived treatment burden. However, determining the risk of psychosocial comorbidities in children with CD remained a challenge. Researchers assessed available research on mental health issues in children with CD for a study and recommended an initial psychosocial research and treatment plan. Databases such as Scopus and PubMed were used. More publications were retrieved and evaluated from the references supplied by the first discovered papers. Two investigators used preset criteria to screen studies (peer-reviewed, published in English, electronically available, inclusive of child participants, and examining CD). The first investigator extracted the data, which the second investigator then reviewed.

Twenty-six publications satisfied the present study’s criteria (16 case-control, 9 observational, and 1 clinical trial). The symptoms studied, the methods used, and the characteristics of the population were all different in the publications. Several studies have revealed that children with CD have an increased risk of psychiatric comorbidities and a worse quality of life. Many research, however, was restricted by small sample numbers and unreliable or nonvalidated methods of evaluating psychological symptoms.

Much previous research has revealed an increased frequency of accompanying CD and psychiatric symptoms or disorders. As a result, screening for psychological symptoms in CD patients and screening for CD in psychological clinic groups is required. Researchers underlined the significance of future research into causes and risks and early goals for pediatric CD psychosocial research and clinical care.