Children with atopic dermatitis (AD) had an 8% greater risk for fracture events overall than those without AD, according to a study published in Pediatric Allergy and Immunology. Eun Kyo Ha, MD, MS, and colleagues examined the association of AD with fracture and sought to identify potential mediating factors. The researchers conducted a retrospective cohort study of children with and without AD from a longitudinal matched cohort database. They investigated accidental fracture events between the index date and the end of follow-up in a propensity score-matched cohort. A total of 145,704 children were included (20% with AD; 49% female). Fractures occurred in 6,652 children with AD (23%; mean age, 64.6±29.2 months) and in 24,698 of the control group (21%; mean age, 65.0±28.9 months). Duration of systemic corticosteroid prescription was the largest mediating factor, followed by a duration of antihistamine prescription and infant feeding practices, the study authors wrote.
