In recent years, there has been a significant rise in the number of therapeutic alternatives for the therapy of lower urinary tract symptoms (LUTS) caused by benign prostatic enlargement (BPE). However, the best time to begin medical treatment for LUTS/BPE was yet to be determined. For a review, researchers collected existing information on the impact of early therapy on the natural history of patients with LUTS/BPE in a systematic manner. From January 1996 to April 2018, a systematic literature search was conducted using the following MESH terms: Lower Urinary Tract Symptoms, Benign Prostatic Enlargement, male, medical therapy, surgical treatment, early treatment/intervention, and early intervention/treatment. The databases Medline, PubMed, and Scopus were searched. Each article’s title and abstract were scrutinized for relevance and suitability to the topic of the study. The medical arsenal for the therapy of LUTS owing to BPE had been widely deployed in recent years, greatly increasing treatment results and lowering the need for BPE surgery. When compared to a postponed strategy, early intervention in patients at risk of illness development might provide superior clinical results. However, data supporting early therapy was limited, and criteria for identifying individuals who might benefit most from immediate treatment were yet poorly defined. Furthermore, individuals getting surgical relief had bigger prostates, were older, and had comorbidities as a result of delayed surgery following lengthy medicinal therapy. Nonetheless, technical advances in surgical methods had largely outweighed the crucial scenario, and a non-detrimental trend in perioperative complications had been documented on a regular basis.

The best time to begin medical treatment in LUTS/BPE patients was still unknown, and surprisingly, peer-reviewed information was scant. More research was needed to better identify people who will benefit most from early treatment of LUTS/BPE.