The goal of this review is to provide a description of the medical conditions in which the use of molecular allergy diagnostics (MAD) has an impact on clinical outcomes such as laboratory diagnoses, prognosis, and allergy therapy. A survey of the literature during the last two years yielded a diverse set of results on this subject. As expected, not all were achieved by the application of MAD, but there is a strong pattern in general.

Among the numerous works accessible, laboratory allergy diagnostics appears to be the most often debated topic, especially given the complexity of the biological context in which these assays are applied. Some intriguing news has emerged regarding MAD’s prognostic potential, whereas for allergen immunotherapy, while awaiting a well-conducted prospective randomised clinical trial, data from retrospective investigations indicates the added values of MAD in the care of allergic patients.