The salvage therapy for esophageal cancer following the chemo-radiation therapy plays a vital role in providing for the care and protection which is ideally required to be evaluated by the endoscopic submucosal dissection. This is also based on the salvage therapy which is then based on histopathological features of the lesions. Therefore, various studies have been conducted so far, and hence, one of such studies included the fact that 10 lesions were compared in at least 8 patients, and hence, it was all with local and residual and recurrent or metachronous esophageal squamous cell carcinoma. Usually, they were the pens who were suffering from this deadly disease and hence, an attempt was made to calculate the data in the best possible manner. It was discovered that the en bloc resection rate was around 100 percent and hence, while the complete resection rate was around 80 percent in the lesions after CRT, indicating no difference between the CRT and non-CRT groups. However, for the patients who had already been diagnosed by severe submucosal fibrosis, it was observed that only in one lesion in the CRT group was very significant and hence, the remaining were less than ph<1. The conclusions were reported to showcase a positive relationship between the elements in the best possible manner and hence, it was also observed that the people could get into the capacity of reporting for work as soon as possible.