Researchers conducted a cohort study that looked back. For a study, they sought to compare the clinical results, radiological data, and perioperative complications of anterolateral lumbar interbody fusion (ALLIF) with minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for the treatment of low-grade lumbar spondylolisthesis. According to the treatment approach, 112 patients with low-grade lumbar spondylolisthesis were divided into MIS-TLIF (n=59, mean age 61.7 y) and ALLIF (n=53, mean age 60.1 y). The length of hospital stay, operation time, and intraoperative blood loss were all reported. In addition, the visual analog scale and the Oswestry disability index score were used to assess clinical outcomes. Disc height, lumbar lordosis, segmental lordosis, and fusion rate were measured using radiographic measures. In comparison to MIS-TLIF, ALLIF considerably reduced operational time, intraoperative blood loss, and length of hospital stay. Furthermore, ALLIF outperformed MIS-TLIF in early postoperative back pain alleviation and lumbar function recovery. However, there were no significant changes in clinical outcomes between the 2 groups at the final follow-up. In the ALLIF group, the amount of change in disc height, lumbar lordosis, and segmental lordosis between preoperative and postoperative were substantially more significant than in the MIS-TLIF group (P<0.05). However, there were no significant differences between the 2 groups regarding fusion rate or complication rate. In the study, the final clinical results and complication rate of ALLIF for treating low-grade lumbar spondylolisthesis were similar to those of MIS-TLIF. ALLIF, on the other hand, demonstrated benefits in terms of more minor surgical trauma, faster recovery, early postoperative back pain alleviation, and improved radiographic characteristics.