For a study, researchers sought to understand that the ideal timing of intubation is disputable. They endeavored to research the relationship between the timing of intubation and clinical results of fundamentally sick patients. PubMed was efficiently focused on writing about the mortality of fundamentally sick patients going through early versus late intubation. Studies including patients with new Covid infection (COVID-19) were prohibited because an important meta-investigation has been distributed. “The creators of the included examinations characterized early” intubation. All-cause mortality was the actual result. Pooled risk proportion (RR) and 95% CI were determined utilizing an irregular impacts model. The meta-examination was enlisted with PROSPERO (CRD42021284850). Altogether, 27 examinations including 15,441 intubated patients (11,943 mid, 3,498 late) were incorporated. All-cause mortality was lower in patients going through early vs. late intubation (7,338 passings; 45.8% vs. 53.5%; RR 0.92, 95% CI 0.87-0.97; P=0.001). This was likewise the situation in the awareness examination of studies characterizing “right on time” as intubation within 24 h from confirmation in the emergency unit (6279 deaths; 45.8% vs. 53.6%; RR 0.93, 95% CI 0.89-0.98; P=0.005). Staying away from late intubation might be related to lower mortality in fundamentally sick patients without COVID-19.