The main of this study is to understand how Patients with intermittent claudication (IC) rely on accurate information regarding their clinical course to make treatment decisions. However, the existing practice guidelines reference outdated natural history studies. We present the 5-year contemporary clinical course of a real-world cohort with IC.

We performed a retrospective cohort study of adults (age, >40 years) with IC evaluated at two tertiary vascular surgery centers between April 1, 2013 and March 31, 2018. The cohort was defined using vascular ultrasound scans and clinic visit records. Outcome follow-up for ≤5 years from the index ultrasound date was ascertained through linkage to population-based administrative health databases for the province of Ontario. The primary outcome was major amputation or urgent revascularization, with elective revascularization and death as competing risks. Secondary outcomes included all-cause mortality, major amputation or death, and myocardial infarction, stroke. or death. The association between the incidence of the primary outcome and patient and disease characteristics was evaluated through univariable Fine and Gray regression.

Reference link-