We live in distressing occasions. It is assessed that about half of grown-ups experience a horrendous mishap at any rate once in the course of their life [1]. Serious or drawn out pressure can cause long haul physiological modification in the cerebrum, and at times brings about the improvement of nervousness problems and post-awful pressure issue (PTSD). At the point when confronted with an unpleasant circumstance, enactment of the hypothalamic–pituitary–adrenal (HPA) hub brings about arrival of adrenal glucocorticoids (GC), cortisol in people, and corticosterone (CORT) in rodents, which essentially acts through mineralocorticoid and glucocorticoid receptors (MR and GR) in the mammalian mind. These perceptions uphold the requirement for proceeding with examination concerning the conceivably contradicting impacts of CORT on the physiological and social sequelae of stress openness. 

Work from Chattarji and associates has recently indicated that a solitary openness to 2 h of immobilization stress prompts a critical expansion in spine thickness in head neurons of the BLA that is obvious 10 days, yet not 1 day, after pressure openness [5]. A postponed beginning expansion in nervousness like conduct is likewise seen at the 10-day time point. This has prompted the obvious conclusion that CORT coordinates the inconvenient impacts of pressure, with BLA hyperactivity being one of the key effectors.

Reference link- https://www.nature.com/articles/s41386-020-00796-4