For adults with severe COVID-19 pneumonia, no signifi cant diff erences are seen in clinical status or mortality for those receiving convalescent plasma versus placebo, according to a study published in the New England Journal of Medicine. Researchers randomly assigned hospitalized adult patients with severe COVID-19 pneumonia to receive either convalescent plasma or placebo in a 2:1 ratio (228 and 105 patients, respectively). The patients’ clinical status 30 days after the intervention was measured on a 6-point ordinal scale ranging from total recovery to death. The study team observed no signifi cant difference between the convalescent plasma and placebo groups in the distribution of clinical outcomes according to the ordinal scale at day 30 (odds ratio, 0.83). Overall mortality rates were 10.96% and 11.43% in the convalescent plasma and placebo groups, respectively, for a risk difference of −0.46%. At day 2 after the intervention, total SARS-CoV-2 antibody titers tended to be higher in the convalescent plasma group. The two groups reported similar adverse, and serious adverse, events. “We believe the use of convalescent plasma as a standard of care in such patients should be reevaluated,” the study authors write.