COVID-19 vaccines are eff ective against SARSCoV-2 infection requiring hospitalization, ICU admission, and emergency department (ED) or urgent care clinic visits, even in populations disproportionately aff ected by SARS-CoV-2 infection, according to a study published in the New England Journal of Medicine. Data from 41,552 admissions to 187 hospitals and 21,522 visits to 221 EDs or urgent care clinics from January 1 through June 22, 2021 showed that the eff ectiveness rates of full mRNA vaccination were 89%, 90%, and 91% against confi rmed SARS-CoV-2 infection leading to hospitalization, ICU admission, or an ED or urgent care clinic visit, respectively. Full vaccination was similarly eff ective for the BNT162b2 and mRNA-1273 vaccines.