Colorectal cancer is the third most common type of cancer and the third leading cause of death from cancer. A research study determined that there was a difference in the colonic microbiome between people with colorectal cancer and the healthy population. Research studies also looked at whether there’s a correlation between the adenoma-carcinoma sequence and CRC progression. CRC microbiomes research also considered how they contributed to CRC carcinogenesis and eventually led to CRC. This allowed for new preventive approaches and treatments. Researchers first highlighted what was wrong with current microbiome research. This was followed by potential solutions for investigating the microbiome’s role in the adenoma-carcinoma sequence. The researchers studied some findings that investigated two major carcinogenic pathways. It allowed them to summarize the findings. These studies focus on the microbiome and how it may affect the onset of colorectal cancer. They utilize samples from different areas of the gut, such as mucosal tissues, and compare polyps or tumors by genetics, histopathology type (that is, whether they’re mutated), and their location in the colon. 

The following were the key findings from these studies: Fusobacterium linked with right-sided, more advanced, and serrated colon cancers; bacteria usually associated with healthy oral flora present in the colons of individuals with CRC, and people with CRC have biofilms in their colons that are mostly found in the proximal colon.