For a review, researchers wanted to present the most recent information on the most significant factors to consider when creating a prostate imaging and biopsy center of excellence. The use of multiparametric MRI (mp-MRI) has altered how physicians identify and treat patients with prostate cancer. This imaging technique enables more exact identification of regions that are suspected of harboring prostate cancer, allowing for the conduct of targeted mp-MRI-guided biopsies, which have been shown to produce higher cancer detection rates. This technology is now being used by more and more centers all around the world. Obtaining results that are comparable to those published in the literature, on the other hand, might be difficult. A multidisciplinary team, comprising a radiologist, urologist, and pathologist, is required for the imaging and biopsy process. Accurate biopsy findings are determined by adequate mp-MRI interpretation for accurate lesion identification, familiarity with the biopsy technique used, and exact characterization of Gleason Score/Grade Groupings. Furthermore, in order to get the best outcomes, all professionals must complete relevant learning curves.