Cerebral vein thrombosis (CVT) incidence was found to be comparable to that registered in population-based studies reported after 2000, according to a large epidemiological study published in Stroke. Investigators identified primary and secondary discharge diagnoses of pyogenic/ nonpyogenic CVT using ICD codes. Concomitant presence of intracerebral hemorrhage (ICH) was registered, and comorbidities were assessed through the Charlson comorbidity index. A total of 1,718 patients were hospitalized for CVT (1,147 females [66.8%;] 810 pyogenic and 908 nonpyogenic CVT, 47.1% and 52.9%, respectively), with 134 patients (7.8%) experiencing a concomitant ICH. The overall incidence rate for CVT was 11.6 per million inhabitants, with sex-specific rates of 15.1 and 7.8 per million in females and males, respectively. CVT incidence significantly increased in women during the time of observation, with the highest incidence rates at ages 40-44 (27.0 cases per million). In-hospital case-fatality rate (CFR) was 3%, with no difference between pyogenic/nonpyogenic CVT. Patients with concomitant ICH had a higher in-hospital CFR compared with patients without ICH (7.5% vs 2.7%; OR, 2.96 [95% CI, 1.45–6.04]). In-hospital CFR progressively increased with increasing Charlson comorbidity index. Age (OR, 1.03), Charlson comorbidity index of 4 or greater (OR, 4.33), and ICH (OR, 3.05) were independent predictors of in-hospital mortality.